https://wikimd.org/index.php?action=history&feed=atom&title=BST1BST1 - Revision history2026-05-13T08:58:35ZRevision history for this page on the wikiMediaWiki 1.44.2https://wikimd.org/index.php?title=BST1&diff=5377906&oldid=prevPrab: CSV import2024-03-09T21:09:58Z<p>CSV import</p>
<p><b>New page</b></p><div>'''BST1''' or '''Bone Marrow Stromal Antigen 1''' is a protein that in humans is encoded by the BST1 gene. It is also known as '''CD157''' and '''Bone Marrow Stromal Cell Antigen 1'''. <br />
<br />
== Function ==<br />
BST1 is an enzyme that catalyzes the synthesis of cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. It is also involved in the mobilization of neutrophils. This protein is prominently expressed on the surface of [[bone marrow]] stromal cells, which is why it is often referred to as Bone Marrow Stromal Antigen 1.<br />
<br />
== Clinical Significance ==<br />
Mutations in the BST1 gene have been associated with [[Parkinson's disease]]. Studies have shown that the BST1 gene may play a role in the pathogenesis of Parkinson's disease, although the exact mechanism is not yet fully understood. <br />
<br />
== Structure ==<br />
The BST1 protein is a member of the ADP-ribosyl cyclase family. It has a molecular weight of approximately 42 kDa and is composed of 382 amino acids. The protein has two main domains: an extracellular domain and a transmembrane domain.<br />
<br />
== See Also ==<br />
* [[ADP-ribosyl cyclase]]<br />
* [[Parkinson's disease]]<br />
* [[Bone marrow]]<br />
<br />
== References ==<br />
<references /><br />
<br />
[[Category:Human proteins]]<br />
[[Category:Enzymes]]<br />
[[Category:Genes associated with Parkinson's disease]]<br />
<br />
{{medicine-stub}}</div>Prab