https://wikimd.org/index.php?action=history&feed=atom&title=BMI1BMI1 - Revision history2026-04-25T09:33:22ZRevision history for this page on the wikiMediaWiki 1.44.2https://wikimd.org/index.php?title=BMI1&diff=5382258&oldid=prevPrab: CSV import2024-03-10T19:48:10Z<p>CSV import</p>
<p><b>New page</b></p><div>'''BMI1''' (B lymphoma Mo-MLV insertion region 1 homolog) is a [[protein]] that in humans is encoded by the ''BMI1'' [[gene]]. It is a member of the [[Polycomb-group]] (PcG) family. PcG family members are known to form protein complexes that are involved in maintaining the [[transcriptional]] repressive state of genes over successive cell generations.<br />
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== Function ==<br />
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The ''BMI1'' gene is a [[proto-oncogene]] that functions as a transcriptional repressor. It plays a critical role in [[cell cycle]] regulation, [[cellular senescence]], and [[stem cell]] renewal. The protein encoded by this gene is a component of the [[Polycomb repressive complex 1]] (PRC1), a complex which has been shown to be involved in the maintenance of [[gene silencing]] and the regulation of [[transcription]]. <br />
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== Clinical significance ==<br />
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Alterations in ''BMI1'' expression have been implicated in several types of [[cancer]], including [[breast cancer]], [[colorectal cancer]], and [[glioma]]. Overexpression of ''BMI1'' has been associated with poor prognosis in several types of cancer. In addition, ''BMI1'' has been identified as a potential therapeutic target in cancer treatment.<br />
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== See also ==<br />
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* [[Polycomb-group]]<br />
* [[Proto-oncogene]]<br />
* [[Gene silencing]]<br />
* [[Transcription (genetics)]]<br />
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== References ==<br />
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{{Reflist}}<br />
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[[Category:Genes]]<br />
[[Category:Oncogenes]]<br />
[[Category:Transcription factors]]<br />
[[Category:Proteins]]<br />
[[Category:Cell biology]]<br />
[[Category:Cancer]]<br />
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{{gene-stub}}<br />
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