https://wikimd.org/index.php?action=history&feed=atom&title=B-cell_maturation_antigenB-cell maturation antigen - Revision history2026-04-26T22:49:17ZRevision history for this page on the wikiMediaWiki 1.44.2https://wikimd.org/index.php?title=B-cell_maturation_antigen&diff=5450495&oldid=prevPrabhu at 22:09, 24 March 20242024-03-24T22:09:01Z<p></p>
<p><b>New page</b></p><div>'''B-cell maturation antigen''' (BCMA), also known as '''CD269''' (Cluster of Differentiation 269), is a protein that in humans is encoded by the TNFRSF17 gene. BCMA is a member of the [[TNF-receptor superfamily]] and plays a key role in [[B cell]] development, survival and function.<br />
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== Structure ==<br />
BCMA is a type I transmembrane protein that is predominantly expressed in [[plasma cell]]s. It is a receptor for [[B-cell activating factor]] (BAFF) and [[a proliferation-inducing ligand]] (APRIL), two members of the [[TNF superfamily]] of cytokines. The binding of these ligands to BCMA promotes B cell survival and enhances their immune response.<br />
[[File:Protein TNFRSF17 PDB 1oqd.png|thumb|alt=Protein_TNFRSF17_PDB_1oqd]]<br />
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== Function ==<br />
* BCMA is essential for the survival of long-lived plasma cells, the cells that produce [[antibody|antibodies]] in response to [[infection]] or [[vaccination]]. It does this by activating [[NF-kappa B]] and [[MAPK8/JNK]] signaling pathways, which promote cell survival and proliferation.<br />
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* BCMA also plays a role in the development of [[multiple myeloma]], a type of [[cancer]] that forms in plasma cells. In multiple myeloma, BCMA is highly expressed on the surface of the cancer cells, making it a potential target for [[cancer therapy]].<br />
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== Clinical significance ==<br />
Due to its role in B cell survival and function, BCMA is being explored as a target for the treatment of B cell-related diseases, including multiple myeloma and [[autoimmune disease]]s. Several therapies that target BCMA, including [[monoclonal antibody]] therapies and [[CAR T-cell therapy]], are currently in clinical trials.<br />
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== See also ==<br />
* [[B-cell activating factor]]<br />
* [[A proliferation-inducing ligand]]<br />
* [[Multiple myeloma]]<br />
* [[Monoclonal antibody therapy]]<br />
* [[CAR T-cell therapy]]<br />
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== References ==<br />
<references /><br />
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{{Clusters of differentiation}}<br />
{{Cytokine receptor modulators}}<br />
* [[Category:Protein domains]]<br />
* [[Category:Clusters of differentiation]]<br />
* [[Category:TNF receptor family]]<br />
* [[Category:Immunology]]<br />
* [[Category:Proteins]]<br />
* [[Category:Oncology]]<br />
* [[Category:Autoimmune diseases]]<br />
* [[Category:Medicine]]<br />
{{medicine-stub}}</div>Prabhu