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Sushmi.n at 19:23, 7 July 2021

2021-07-07T19:23:49Z

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=='''What is Avatrombopag?'''==

Avatrombopag is a '''thrombopoietin receptor agonist'''.

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=='''What are the uses of this medicine?'''==

*This medication is indicated for the treatment of [[thrombocytopenia]] in adult patients with chronic liver disease who are scheduled to undergo a procedure or with chronic immune thrombocytopenia who have had an insufficient response to a previous treatment.

=='''How does this medicine work?'''==

*Avatrombopag is an orally bioavailable, small molecule [[thrombopoietin receptor gene|thrombopoietin (TPO) receptor]] agonist that results in an increased production of platelets.
*This medication does not compete with TPO for binding to the TPO receptor and has an additive effect with TPO on platelet production.

=='''Who should not use this medicine?'''==

This medicine cannot be used for:

*Patients with [[chronic liver disease]] in an attempt to normalize platelet counts.
*Patients with chronic immune thrombocytopenia in an attempt to normalize platelet counts.

=='''Is this medicine FDA approved?'''==

*Avatrombopag was approved for use in the United States in 2018.

=='''How should this medicine be administered?'''==

For patients with chronic liver disease:

*Begin DOPTELET dosing based upon platelet count 10 to 13 days prior to the scheduled procedure.
*Take DOPTELET orally once daily for 5 consecutive days with food.
*For platelet count less than 40x109/L, the dose is 60 mg (3 tablets) once daily; for platelet count 40 to less than 50x109/L the dose is 40 mg (2 tablets) once daily.
*In the case of a missed dose, patients should take the next dose of DOPTELET as soon as they remember. Patients should not take two doses at one time to make up for a missed dose, and should take the next dose at the usual time the next day; all 5 days of dosing should be completed.

For patients with chronic immune thrombocytopenia:

*Initiate DOPTELET at 20 mg (1 tablet) once daily.
*Adjust the dose or frequency of dosing to maintain platelet count greater than or equal to 50x109/L.
*Do not exceed 40 mg per day.

=='''What are the dosage forms and brand names of this medicine?'''==

This medicine is available in the following dosage form:

*20 mg tablets

This medicine is available in the following brand nameː '''DOPTELET'''

=='''What side effects can this medication cause?'''==

Common possible side effects of this medicine when used to treat low blood platelet counts in adults with chronic liver disease(CLD) who are scheduled to have a medical or dental procedure include:

*[[fever]]

*[[headache]]

*[[stomach pain]]

*[[tiredness]]

*[[nausea]]

*[[swelling of hands]] or [[feet]]

Common possible side effects of this medicine when used to treat low blood platelet counts in adults with chronic immune thrombocytopenia (ITP) include:

*[[headache]]

*[[joint pain]]

*[[tiredness]]

*[[bleeding gums]]

*[[bruising]]

*purple or red spots on your skin

*[[nosebleed]]

*[[runny nose]]

*[[upper respiratory tract infection]]

Serious possible side effects of this medicine include blood clots and may cause symptoms such as:

*[[swelling]], [[pain]], or [[tenderness]] in your legs

*[[fast heartbeat]]

*[[shortness of breath]]

*[[stomach pain]] or [[tenderness]]

*[[chest pain]]

=='''What special precautions should I follow?'''==

*Follow the dosing guidelines to achieve target platelet counts.
*DOPTELET is a thrombopoietin (TPO) receptor agonist, which is associated with thrombotic and thromboembolic complications in patients with chronic liver disease or chronic immune thrombocytopenia.
*Monitor patients receiving DOPTELET for signs and symptoms of thromboembolic events and institute treatment promptly.

=='''What to do in case of emergency/overdose?'''==

*In the event of overdose, platelet count may increase excessively and result in thrombotic or [[thromboembolic event|thromboembolic complications]]. Closely monitor symptoms and platelet count. Treat thrombotic complications in accordance with standard of care.
*No antidote for DOPTELET overdose is known.

=='''Can this medicine be used in pregnancy?'''==

*Avatrombopag may cause fetal harm when administered to a pregnant woman.

=='''Can this medicine be used in children?'''==

*The safety and effectiveness of Avatrombopag in pediatric patients have not been established.

=='''What should I know about storage of this medication? '''==

*Store at 20°C to 25°C (68°F to 77°F), excursions permitted to 15°C to 30°C (59°F to 86°F).
*Store tablets in the original package.

=='''What are the active and inactive ingredients in this medicine?'''==

*'''Active ingredient:''' avatrombopag

*'''Inactive ingredients:''' lactose monohydrate, colloidal silicon dioxide, crospovidone, magnesium stearate and microcrystalline cellulose. Tablet coating film: polyvinyl alcohol, talc, polyethylene glycol, titanium dioxide and ferric oxide yellow.

=='''Who manufactures and distributes this medicine?'''==

*DOPTELET is a registered trademark of [[AkaRx, Inc]].
*Manufactured for AkaRx, Inc., Durham, North Carolina 27707
*Marketed by Sobi, Inc., Waltham, Massachusetts 02451

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[[Category:Drugs acting on the blood and blood forming organs]]
[[Category:Orphan drugs]]
[[Category:Thrombopoietin receptor agonists]]
[[Category:Thiophenes]]
[[Category:Chloropyridines]]
[[Category:Thiazoles]]
[[Category:Piperazines]]

Avatrombopag - Revision history

Prab: CSV import

Prab: CSV import

Prab: CSV import

Sushmi.n at 19:23, 7 July 2021