Auto-brewery syndrome - Revision history

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2025-04-04T16:50:37Z

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← Older revision		Revision as of 16:50, 4 April 2025
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			{{SI}}
			{{Infobox medical condition
			\| name = Auto-brewery syndrome
			\| image = [[File:2401_Components_of_the_Digestive_System.jpg\|left\|thumb\|Digestive system components]]
			\| caption = Components of the digestive system
			\| synonyms = Gut fermentation syndrome, endogenous ethanol fermentation
			\| field = [[Gastroenterology]]
			\| symptoms = [[Intoxication]], [[dizziness]], [[headache]], [[dry mouth]], [[hangover]]
			\| complications = [[Liver disease]], [[pancreatitis]]
			\| onset = Can occur at any age
			\| duration = Chronic
			\| causes = Overgrowth of [[yeast]] in the [[gastrointestinal tract]]
			\| risks = [[Antibiotic]] use, [[diet high in carbohydrates]]
			\| diagnosis = [[Blood alcohol test]], [[stool culture]]
			\| differential = [[Alcohol use disorder]], [[metabolic disorders]]
			\| prevention = [[Dietary modification]], [[probiotics]]
			\| treatment = [[Antifungal medications]], [[dietary changes]]
			\| medication = [[Fluconazole]], [[nystatin]]
			\| prognosis = Variable, depends on management
			\| frequency = Rare
			}}
	Auto-brewery Syndrome		Auto-brewery Syndrome
			[[File:2401 Components of the Digestive System.jpg\|left\|thumb\|Components of the Digestive System]]
	[[File:2401 Components of the Digestive System.jpg\|thumb\|Components of the Digestive System]]		[[File:Ethanol fermentation.jpg\|left\|thumb\|Ethanol fermentation process]]
	[[File:Ethanol fermentation.jpg\|thumb\|Ethanol fermentation process]]

	'''Auto-brewery syndrome''', also known as '''gut fermentation syndrome''', is a rare medical condition in which intoxicating quantities of ethanol are produced through endogenous fermentation within the digestive system. This condition can lead to symptoms of intoxication without the consumption of alcoholic beverages.		'''Auto-brewery syndrome''', also known as '''gut fermentation syndrome''', is a rare medical condition in which intoxicating quantities of ethanol are produced through endogenous fermentation within the digestive system. This condition can lead to symptoms of intoxication without the consumption of alcoholic beverages.

	==Pathophysiology==		==Pathophysiology==
	Auto-brewery syndrome occurs when certain types of yeast or bacteria in the gastrointestinal tract ferment carbohydrates into ethanol. The most commonly implicated organism is ''[[Saccharomyces cerevisiae]]'', a type of yeast that is also used in baking and brewing. Other organisms, such as ''[[Candida albicans]]'', have also been associated with this condition.		Auto-brewery syndrome occurs when certain types of yeast or bacteria in the gastrointestinal tract ferment carbohydrates into ethanol. The most commonly implicated organism is ''[[Saccharomyces cerevisiae]]'', a type of yeast that is also used in baking and brewing. Other organisms, such as ''[[Candida albicans]]'', have also been associated with this condition.

	The fermentation process is similar to the [[ethanol fermentation]] used in brewing, where sugars are converted into alcohol and carbon dioxide. In individuals with auto-brewery syndrome, this process occurs within the [[digestive system]], leading to elevated blood alcohol levels.		The fermentation process is similar to the [[ethanol fermentation]] used in brewing, where sugars are converted into alcohol and carbon dioxide. In individuals with auto-brewery syndrome, this process occurs within the [[digestive system]], leading to elevated blood alcohol levels.

	==Symptoms==		==Symptoms==
	Symptoms of auto-brewery syndrome can vary but often include:		Symptoms of auto-brewery syndrome can vary but often include:
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	* Hangover-like symptoms		* Hangover-like symptoms
	* Mood changes		* Mood changes

	These symptoms can occur after consuming carbohydrate-rich meals, as the carbohydrates are fermented into alcohol.		These symptoms can occur after consuming carbohydrate-rich meals, as the carbohydrates are fermented into alcohol.

	==Diagnosis==		==Diagnosis==
	Diagnosing auto-brewery syndrome can be challenging due to its rarity and the variability of symptoms. Diagnosis typically involves:		Diagnosing auto-brewery syndrome can be challenging due to its rarity and the variability of symptoms. Diagnosis typically involves:
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	* Stool cultures to identify yeast or bacteria responsible for fermentation.		* Stool cultures to identify yeast or bacteria responsible for fermentation.
	* Dietary history to identify potential triggers.		* Dietary history to identify potential triggers.

	==Treatment==		==Treatment==
	Treatment for auto-brewery syndrome may include:		Treatment for auto-brewery syndrome may include:
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	* Antifungal or antibiotic medications to reduce the population of fermenting organisms in the gut.		* Antifungal or antibiotic medications to reduce the population of fermenting organisms in the gut.
	* Probiotics to restore normal gut flora.		* Probiotics to restore normal gut flora.

	==Prognosis==		==Prognosis==
	With appropriate treatment, many individuals with auto-brewery syndrome can manage their symptoms effectively. However, the condition can be chronic and may require ongoing management.		With appropriate treatment, many individuals with auto-brewery syndrome can manage their symptoms effectively. However, the condition can be chronic and may require ongoing management.

	==Also see==		==Also see==
	* [[Ethanol fermentation]]		* [[Ethanol fermentation]]
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	* [[Candida albicans]]		* [[Candida albicans]]
	* [[Digestive system]]		* [[Digestive system]]

	{{Digestive system diseases}}		{{Digestive system diseases}}
	{{Alcohol-related disorders}}		{{Alcohol-related disorders}}

	[[Category:Rare diseases]]		[[Category:Rare diseases]]
	[[Category:Alcohol-related disorders]]		[[Category:Alcohol-related disorders]]
	[[Category:Gastroenterology]]		[[Category:Gastroenterology]]

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2024-12-11T02:44:39Z

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-[[Auto-brewery syndrome]] (ABS), also referred to as gut fermentation syndrome, endogenous ethanol fermentation, or drunkenness disease, is a rare medical condition characterized by the production of ethanol, an intoxicating substance, within the human body. This is caused by an overgrowth of specific types of yeast and bacteria in the gastrointestinal tract that ferment ingested carbohydrates.
+Auto-brewery Syndrome
-== Pathophysiology ==
+[[File:2401 Components of the Digestive System.jpg|thumb|Components of the Digestive System]]
-The pathogenesis of ABS involves the conversion of dietary carbohydrates into alcohol (ethanol) by microbes residing in the digestive tract. These microbes, predominantly yeasts and bacteria such as Saccharomyces cerevisiae, S. boulardii, Candida species (including C. albicans, C. tropicalis, C. krusei, C. glabrata, and C. kefyr), C. parapsilosis, Klebsiella pneumoniae, and Enterococcus faecium, use lactic acid fermentation or mixed acid fermentation pathways to produce ethanol as an end product.
+'''Auto-brewery syndrome''', also known as '''gut fermentation syndrome''', is a rare medical condition in which intoxicating quantities of ethanol are produced through endogenous fermentation within the digestive system. This condition can lead to symptoms of intoxication without the consumption of alcoholic beverages.
-== Clinical Features ==
+==Pathophysiology==
-Individuals with ABS may experience symptoms of inebriation, including dizziness, disorientation, and slurred speech, despite not consuming alcohol. The onset of these symptoms can occur after meals rich in carbohydrates.
+The fermentation process is similar to the [[ethanol fermentation]] used in brewing, where sugars are converted into alcohol and carbon dioxide. In individuals with auto-brewery syndrome, this process occurs within the [[digestive system]], leading to elevated blood alcohol levels.
-== Diagnosis and Treatment ==
+==Symptoms==
-The diagnosis of ABS is challenging due to its rarity and overlapping symptoms with other conditions. It usually involves tests to measure blood alcohol concentration over time following a carbohydrate-rich meal. Treatment typically includes dietary modifications to limit carbohydrate intake and antibiotics or antifungal medications to reduce the population of fermenting microbes.
+These symptoms can occur after consuming carbohydrate-rich meals, as the carbohydrates are fermented into alcohol.
 [[Category:Rare diseases]]
 [[Category:Gastroenterology]]

Prab at 20:35, 28 June 2023

2023-06-28T20:35:08Z

New page

[[Auto-brewery syndrome]] (ABS), also referred to as gut fermentation syndrome, endogenous ethanol fermentation, or drunkenness disease, is a rare medical condition characterized by the production of ethanol, an intoxicating substance, within the human body. This is caused by an overgrowth of specific types of yeast and bacteria in the gastrointestinal tract that ferment ingested carbohydrates.

== Pathophysiology ==

The pathogenesis of ABS involves the conversion of dietary carbohydrates into alcohol (ethanol) by microbes residing in the digestive tract. These microbes, predominantly yeasts and bacteria such as Saccharomyces cerevisiae, S. boulardii, Candida species (including C. albicans, C. tropicalis, C. krusei, C. glabrata, and C. kefyr), C. parapsilosis, Klebsiella pneumoniae, and Enterococcus faecium, use lactic acid fermentation or mixed acid fermentation pathways to produce ethanol as an end product.

== Clinical Features ==

Individuals with ABS may experience symptoms of inebriation, including dizziness, disorientation, and slurred speech, despite not consuming alcohol. The onset of these symptoms can occur after meals rich in carbohydrates.

== Diagnosis and Treatment ==

The diagnosis of ABS is challenging due to its rarity and overlapping symptoms with other conditions. It usually involves tests to measure blood alcohol concentration over time following a carbohydrate-rich meal. Treatment typically includes dietary modifications to limit carbohydrate intake and antibiotics or antifungal medications to reduce the population of fermenting microbes.

[[Category:Rare diseases]]
[[Category:Gastroenterology]]
[[Category:Metabolic disorders]]
{{stub}}
== References ==
<references/>
# Cordell B, Kanodia A, Miller GK. "Case-control research study of Auto-Brewery Syndrome." Global Advances in Health and Medicine. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6648766/ Case-control research study of Auto-Brewery Syndrome]
# Spinucci G, Guidetti M, Lanzoni E, Pironi L. "Endogenous ethanol production in a patient with chronic intestinal pseudo-obstruction and small intestinal bacterial overgrowth." European Journal of Gastroenterology & Hepatology. [https://journals.lww.com/eurojgh/Abstract/2006/06000/Endogenous_ethanol_production_in_a_patient_with.22.aspx Endogenous ethanol production]
# Yokoyama A, Omori T. "Auto-Brewery Syndrome (Gut Fermentation)." BioPsychoSocial Medicine. [https://bpsmedicine.biomedcentral.com/articles/10.1186/1751-0759-7-11 Journal article]