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<p><b>New page</b></p><div>[[File:Arterolane.png|thumb|{{PAGENAME}}]]<br>'''Arterolane''' is a synthetic [[antimalarial]] compound. It is a member of the class of drugs known as [[ozonides]], which are synthetic peroxide-containing compounds. Arterolane was developed by the Medicines for Malaria Venture (MMV) and Ranbaxy Laboratories Limited. <br />
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== History ==<br />
Arterolane was first synthesized in the late 1990s by a team of scientists at the University of Nebraska. The compound was developed as part of a larger effort to create new antimalarial drugs that could overcome the problem of [[drug resistance]] in malaria parasites. <br />
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== Mechanism of Action ==<br />
Arterolane's mechanism of action is similar to that of other ozonides. It is believed to work by generating reactive oxygen species within the malaria parasite, which then damage the parasite's cells and lead to its death. <br />
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== Clinical Use ==<br />
Arterolane is used in combination with [[piperaquine]], a long-acting antimalarial drug, to treat uncomplicated [[Plasmodium falciparum]] malaria. The combination of arterolane and piperaquine has been shown to be effective in clinical trials and is recommended by the World Health Organization for the treatment of uncomplicated P. falciparum malaria in areas where the parasite is resistant to other antimalarial drugs.<br />
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== Side Effects ==<br />
The most common side effects of arterolane are nausea, vomiting, and abdominal pain. These side effects are generally mild and temporary. <br />
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== Future Research ==<br />
Future research on arterolane is likely to focus on its potential use in combination with other antimalarial drugs, as well as its potential use in the treatment of other parasitic diseases.<br />
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[[Category:Antimalarial agents]]<br />
[[Category:Ozonides]]<br />
{{Antimalarial agents}}<br />
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