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Apelin - Revision history
2026-05-14T14:17:28Z
Revision history for this page on the wiki
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https://wikimd.org/index.php?title=Apelin&diff=6527466&oldid=prev
Prab at 17:14, 18 March 2025
2025-03-18T17:14:47Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 17:14, 18 March 2025</td>
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Prab
https://wikimd.org/index.php?title=Apelin&diff=6498148&oldid=prev
Prab: CSV import
2025-03-17T04:26:55Z
<p>CSV import</p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 04:26, 17 March 2025</td>
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Prab
https://wikimd.org/index.php?title=Apelin&diff=6212365&oldid=prev
Prab: CSV import
2025-02-10T06:56:54Z
<p>CSV import</p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 06:56, 10 February 2025</td>
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Prab
https://wikimd.org/index.php?title=Apelin&diff=5327662&oldid=prev
Prab: CSV import
2024-02-28T22:44:42Z
<p>CSV import</p>
<p><b>New page</b></p><div>'''Apelin''' is a [[peptide]] that is encoded by the APLN [[gene]] in humans. It is widely expressed in various tissues, including the [[heart]], [[lung]], [[kidney]], [[liver]], [[adipose tissue]], and [[central nervous system]]. Apelin is known to have several important physiological roles, such as regulating [[blood pressure]], [[cardiac contractility]], and [[fluid balance]]. It is also involved in the pathophysiology of several diseases, including [[cardiovascular disease]], [[diabetes]], and [[obesity]].<br />
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== Structure and Function ==<br />
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Apelin is a 77-amino acid prepropeptide that is cleaved to produce active peptides of varying lengths. The most common forms are apelin-36, apelin-17, apelin-13, and [Pyr1]apelin-13. These peptides bind to the apelin [[receptor]], also known as APJ, which is a [[G protein-coupled receptor]].<br />
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The binding of apelin to its receptor triggers a cascade of intracellular events that lead to various physiological responses. For example, in the cardiovascular system, apelin promotes [[vasodilation]], reduces [[cardiac preload]] and [[afterload]], and enhances cardiac contractility. In the kidney, it promotes [[diuresis]] and [[natriuresis]]. In the central nervous system, apelin regulates [[energy metabolism]] and [[food intake]].<br />
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== Clinical Significance ==<br />
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Apelin has been implicated in several diseases. In cardiovascular disease, decreased levels of apelin have been associated with [[heart failure]], [[hypertension]], and [[atherosclerosis]]. In diabetes, apelin improves [[insulin sensitivity]] and glucose uptake in [[skeletal muscle]]. In obesity, apelin regulates adipocyte differentiation and lipid metabolism.<br />
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There is also evidence that apelin may have therapeutic potential. For example, apelin analogs have been shown to improve cardiac function in animal models of heart failure. In addition, apelin has been proposed as a potential biomarker for various diseases, including heart failure and diabetes.<br />
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== See Also ==<br />
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* [[Peptide]]<br />
* [[G protein-coupled receptor]]<br />
* [[Cardiovascular disease]]<br />
* [[Diabetes]]<br />
* [[Obesity]]<br />
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== References ==<br />
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{{reflist}}<br />
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[[Category:Peptides]]<br />
[[Category:Human proteins]]<br />
[[Category:Cardiovascular physiology]]<br />
[[Category:Endocrinology]]<br />
[[Category:Diabetes]]<br />
[[Category:Obesity]]<br />
{{protein-stub}}<br />
{{medicine-stub}}</div>
Prab