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2025-02-18T04:38:42Z

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← Older revision		Revision as of 04:38, 18 February 2025
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	[[Category:Renin–angiotensin system]]		[[Category:Renin–angiotensin system]]
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			<gallery>
			File:4asq.jpg\|Angiotensin-converting enzyme
			File:ACE_mechanism.png\|Mechanism of action of ACE
			File:Renin-angiotensin-aldosterone_system.svg\|Renin-angiotensin-aldosterone system
			File:Renin-angiotensin_system_in_man_shadow.svg\|Renin-angiotensin system in humans
			File:ACE_in_complex_with_inhibitor_lisinopril.png\|ACE in complex with inhibitor lisinopril
			</gallery>

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2024-03-03T05:43:39Z

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'''Angiotensin-converting enzyme''' (often abbreviated as '''ACE''') is an [[enzyme]] that plays a crucial role in the [[renin–angiotensin system]] (RAS), which regulates [[blood pressure]] and fluid balance in the body. ACE converts the hormone [[angiotensin I]] into the active vasoconstrictor [[angiotensin II]].

== Function ==

The primary function of ACE is to convert angiotensin I into angiotensin II. Angiotensin II is a potent [[vasoconstrictor]], which means it narrows blood vessels and increases blood pressure. It also stimulates the release of the hormone [[aldosterone]], which promotes the retention of [[sodium]] and water in the kidneys, further increasing blood pressure.

ACE is also involved in the degradation of [[bradykinin]], a potent [[vasodilator]]. By breaking down bradykinin, ACE indirectly increases blood pressure.

== Clinical significance ==

Due to its role in blood pressure regulation, ACE is a target for the treatment of [[hypertension]] and [[heart failure]]. [[ACE inhibitors]] are a class of drugs that inhibit the action of ACE, thereby reducing the production of angiotensin II and the degradation of bradykinin. This results in vasodilation and a reduction in blood pressure.

ACE is also involved in the pathophysiology of [[COVID-19]]. The virus that causes COVID-19, [[SARS-CoV-2]], uses ACE2, a homolog of ACE, to enter cells. This has led to speculation about the potential impact of ACE inhibitors on COVID-19, but the relationship is currently not fully understood.

== See also ==

* [[Renin–angiotensin system]]
* [[ACE inhibitors]]
* [[Hypertension]]
* [[Heart failure]]
* [[COVID-19]]

[[Category:Enzymes]]
[[Category:Cardiovascular system]]
[[Category:Renin–angiotensin system]]
{{enzyme-stub}}

Angiotensin-converting enzyme - Revision history

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