Prab at 17:09, 18 March 2025

2025-03-18T17:09:37Z

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{{Short description|Antivenom for pit viper bites}}
{{Infobox drug
| name = Anavip
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| routes_of_administration = [[Intravenous therapy|Intravenous]]
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'''Anavip''' is an [[antivenom]] used for the treatment of [[envenomation]] by [[pit viper]]s, including [[rattlesnake]]s. It is specifically designed to neutralize the venom of these snakes and is administered via [[intravenous therapy|intravenous]] infusion.
==Composition==
Anavip is composed of [[equine]]-derived [[F(ab')2 fragment]]s of immunoglobulin G (IgG). These fragments are obtained from horses that have been immunized with the venom of pit vipers. The F(ab')2 fragments are purified and processed to remove the Fc portion of the antibody, reducing the risk of adverse immune reactions.
==Indications==
Anavip is indicated for the management of adult and pediatric patients with [[North American pit viper]] envenomation. This includes bites from various species of rattlesnakes, such as the [[Western Diamondback Rattlesnake|western diamondback rattlesnake]] and the [[Eastern Diamondback Rattlesnake|eastern diamondback rattlesnake]].
==Mechanism of Action==
The F(ab')2 fragments in Anavip bind to and neutralize the toxic components of pit viper venom. This prevents the venom from causing further damage to tissues and organs, thereby mitigating the effects of the envenomation.
==Administration==
Anavip is administered intravenously. The initial dose is typically given as soon as possible after the bite, followed by additional doses as needed based on the patient's clinical response. The infusion should be monitored closely for any signs of adverse reactions.
==Adverse Reactions==
Common adverse reactions to Anavip include mild to moderate [[allergic reaction]]s, such as [[rash]], [[itching]], and [[fever]]. Severe reactions, such as [[anaphylaxis]], are rare but can occur. Patients should be monitored for any signs of hypersensitivity during and after the infusion.
==Storage and Handling==
Anavip should be stored in a refrigerator at temperatures between 2°C and 8°C (36°F and 46°F). It should not be frozen. The product should be protected from light and kept in its original packaging until ready for use.
==See Also==
* [[Antivenom]]
* [[Pit viper]]
* [[Rattlesnake]]
* [[Envenomation]]
* [[Intravenous therapy]]
==Related Pages==
* [[Antivenom]]
* [[Pit viper]]
* [[Rattlesnake]]
* [[Envenomation]]
* [[Intravenous therapy]]
[[Category:Antivenoms]]
[[Category:Emergency medicine]]
[[Category:Snakebite]]
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Anavip - Revision history

Prab at 17:09, 18 March 2025

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