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<p><b>New page</b></p><div>[[File:Amodiaquine.svg|thumb|Amodiaquine.svg]] '''Amodiaquine''' is a [[medication]] used to treat and prevent [[malaria]]. It is often used in combination with other antimalarial drugs, such as [[artesunate]] or [[sulfadoxine/pyrimethamine]]. Amodiaquine is a [[4-aminoquinoline]] compound, similar to [[chloroquine]], and it works by interfering with the growth of [[Plasmodium]] parasites in the [[red blood cells]].<br />
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==Medical Uses==<br />
Amodiaquine is primarily used for the treatment of [[uncomplicated malaria]] caused by [[Plasmodium falciparum]] and [[Plasmodium vivax]]. It is also used in [[malaria prophylaxis]] in areas where [[chloroquine]] resistance is prevalent. The drug is often administered as part of a combination therapy to reduce the risk of resistance development.<br />
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==Mechanism of Action==<br />
Amodiaquine works by inhibiting the [[heme polymerase]] activity in the [[Plasmodium]] parasites. This inhibition leads to the accumulation of toxic heme within the parasite, ultimately causing its death. The drug is effective against the [[erythrocytic stage]] of the parasite's life cycle.<br />
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==Side Effects==<br />
Common side effects of amodiaquine include [[nausea]], [[vomiting]], [[abdominal pain]], and [[headache]]. Serious side effects can include [[hepatotoxicity]], [[agranulocytosis]], and [[aplastic anemia]]. Due to these potential risks, the use of amodiaquine is generally limited to areas where the benefits outweigh the risks.<br />
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==Pharmacokinetics==<br />
Amodiaquine is well absorbed from the [[gastrointestinal tract]] and is metabolized in the [[liver]] to its active metabolite, [[desethylamodiaquine]]. The drug and its metabolites are excreted primarily in the [[urine]].<br />
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==History==<br />
Amodiaquine was first synthesized in the 1940s and has been used extensively in the treatment of malaria. However, its use declined due to the emergence of drug-resistant strains of [[Plasmodium falciparum]] and concerns over its safety profile. In recent years, it has seen a resurgence in use as part of combination therapies.<br />
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==Research==<br />
Ongoing research is focused on improving the efficacy and safety of amodiaquine, as well as developing new combination therapies to combat drug-resistant malaria strains.<br />
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==See Also==<br />
* [[Malaria]]<br />
* [[Antimalarial medication]]<br />
* [[Plasmodium falciparum]]<br />
* [[Plasmodium vivax]]<br />
* [[Chloroquine]]<br />
* [[Artesunate]]<br />
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==References==<br />
{{Reflist}}<br />
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==External Links==<br />
{{Commons category|Amodiaquine}}<br />
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[[Category:Antimalarial agents]]<br />
[[Category:4-Aminoquinolines]]<br />
[[Category:World Health Organization essential medicines]]<br />
[[Category:Medicine]]<br />
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