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<p><b>New page</b></p><div>{{Short description|An encyclopedia article about Amfonelic acid}}<br />
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[[File:Amfonelic_acid.png|thumb|right|Chemical structure of Amfonelic acid]]<br />
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'''Amfonelic acid''' is a research chemical that acts as a potent and selective [[dopamine reuptake inhibitor]]. It was originally developed in the 1960s as a potential treatment for [[Parkinson's disease]] and [[depression]], but it was never marketed for medical use.<br />
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==Pharmacology==<br />
Amfonelic acid is known for its ability to inhibit the reuptake of [[dopamine]], a neurotransmitter that plays a key role in the [[central nervous system]]. By preventing the reuptake of dopamine, amfonelic acid increases the concentration of dopamine in the synaptic cleft, thereby enhancing dopaminergic neurotransmission.<br />
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===Mechanism of Action===<br />
Amfonelic acid selectively inhibits the dopamine transporter (DAT), which is responsible for the reuptake of dopamine from the synaptic cleft back into the presynaptic neuron. This inhibition leads to increased levels of dopamine in the synaptic cleft, which can enhance mood, increase alertness, and improve cognitive function.<br />
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==Potential Uses==<br />
Although amfonelic acid was never approved for clinical use, its pharmacological profile suggests potential applications in the treatment of disorders characterized by dopaminergic dysfunction, such as [[Parkinson's disease]], [[attention deficit hyperactivity disorder]] (ADHD), and certain forms of [[depression]].<br />
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==Research==<br />
Research on amfonelic acid has primarily focused on its effects on the dopaminergic system and its potential as a tool for studying dopamine-related disorders. Studies have shown that amfonelic acid can increase locomotor activity in animal models, which is consistent with its role as a dopamine reuptake inhibitor.<br />
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==Safety and Toxicity==<br />
The safety profile of amfonelic acid in humans is not well-documented, as it has not been approved for medical use. However, like other dopamine reuptake inhibitors, it may have the potential for abuse and could lead to side effects such as increased heart rate, hypertension, and anxiety.<br />
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==Related pages==<br />
* [[Dopamine reuptake inhibitor]]<br />
* [[Parkinson's disease]]<br />
* [[Depression (mood)]]<br />
* [[Attention deficit hyperactivity disorder]]<br />
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[[Category:Dopamine reuptake inhibitors]]<br />
[[Category:Research chemicals]]</div>Prab