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<p><b>New page</b></p><div>[[File:Alphacetylmethadol.svg|thumb|{{PAGENAME}}]]<br>'''Alphacetylmethadol''' (also known as '''ACEM''' or '''LAAM''') is a synthetic [[opioid]] used in the treatment of [[opioid addiction]]. It is a long-acting derivative of [[methadone]] and is chemically similar to [[levo-alpha-acetylmethadol]] (LAAM).<br />
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== History ==<br />
Alphacetylmethadol was first synthesized in the 1940s as part of a research program aimed at developing opioid analgesics with improved pharmacological properties. It was later developed as a treatment for opioid addiction in the 1970s.<br />
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== Pharmacology ==<br />
Alphacetylmethadol is a [[mu-opioid receptor]] agonist. It works by mimicking the effects of opioids in the brain, thereby reducing cravings and withdrawal symptoms in opioid-dependent individuals. Alphacetylmethadol is metabolized in the liver and has a long half-life, which allows for less frequent dosing compared to other opioid replacement therapies.<br />
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== Clinical Use ==<br />
Alphacetylmethadol is used in the treatment of opioid addiction. It is typically administered in a clinic setting under the supervision of a healthcare provider. The dosage is individualized based on the patient's opioid tolerance and response to treatment.<br />
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== Side Effects ==<br />
Common side effects of alphacetylmethadol include constipation, drowsiness, and nausea. Serious side effects may include respiratory depression, QT prolongation, and dependence.<br />
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== Legal Status ==<br />
In the United States, alphacetylmethadol is classified as a Schedule II controlled substance, indicating a high potential for abuse and dependence.<br />
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== See Also ==<br />
* [[Methadone]]<br />
* [[Opioid addiction]]<br />
* [[Opioid replacement therapy]]<br />
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[[Category:Opioids]]<br />
[[Category:Drugs used in opioid addiction]]<br />
[[Category:Synthetic opioids]]<br />
{{Opioids}}<br />
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