https://wikimd.org/index.php?action=history&feed=atom&title=Aliflurane 2026-04-26T19:06:26Z Revision history for this page on the wiki MediaWiki 1.44.2 https://wikimd.org/index.php?title=Aliflurane&diff=5368752&oldid=prev 2024-03-06T04:23:56Z

<p>CSV import</p> <p><b>New page</b></p><div>[[File:Aliflurane.png|thumb|{{PAGENAME}}]]&lt;br&gt;&#039;&#039;&#039;Aliflurane&#039;&#039;&#039; is a [[chemical compound]] that was once used as an [[inhalational anesthetic]]. It is a [[fluorinated ether]] that was developed in the mid-20th century but is no longer in common use due to its side effects and the development of safer alternatives.<br /> <br /> == History ==<br /> [[Aliflurane]] was first synthesized in the 1950s as part of a wave of new [[anesthetic]] drugs that were being developed at the time. It was initially hailed as a promising new drug due to its high potency and low solubility, which allowed for rapid induction and recovery from anesthesia. However, it soon became apparent that aliflurane had a number of serious side effects, including [[cardiac arrhythmias]], [[hepatic dysfunction]], and [[neurotoxicity]]. These side effects, combined with the development of safer alternatives, led to aliflurane being phased out of clinical use by the end of the 20th century.<br /> <br /> == Pharmacology ==<br /> [[Aliflurane]] is a [[halogenated ether]], a class of compounds that also includes other anesthetic drugs such as [[desflurane]] and [[sevoflurane]]. Like other ethers, aliflurane works by interacting with [[GABA receptors]] in the brain, enhancing the effect of the inhibitory neurotransmitter [[GABA]] and thereby inducing a state of general anesthesia.<br /> <br /> Despite its high potency, aliflurane has a number of drawbacks that have led to its disuse. It is highly [[lipophilic]], which means it can accumulate in fatty tissues and lead to prolonged recovery times. It is also metabolized by the liver into potentially toxic compounds, which can cause [[hepatic dysfunction]] and other side effects.<br /> <br /> == Current status ==<br /> Today, [[aliflurane]] is rarely used in clinical practice. It is occasionally used in veterinary medicine, but even in this context, it is generally considered a drug of last resort. The development of newer, safer anesthetic drugs has largely rendered aliflurane obsolete.<br /> <br /> == See also ==<br /> * [[Anesthesia]]<br /> * [[Inhalational anesthetic]]<br /> * [[Halogenated ether]]<br /> <br /> [[Category:Anesthetics]]<br /> [[Category:Fluorinated ethers]]<br /> [[Category:Obsolete drugs]]<br /> {{Anesthesia-stub}}<br /> {{Pharmacology-stub}}</div>

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