https://wikimd.org/index.php?action=history&feed=atom&title=AldosteroneAldosterone - Revision history2026-04-26T11:48:48ZRevision history for this page on the wikiMediaWiki 1.44.2https://wikimd.org/index.php?title=Aldosterone&diff=4972060&oldid=prevPrab at 05:43, 11 October 20232023-10-11T05:43:56Z<p></p>
<p><b>New page</b></p><div>==Aldosterone==<br />
[[File:Aldosterone.svg|thumb|Aldosterone molecular structure]]<br />
'''Aldosterone''' is a mineralocorticoid hormone produced by the adrenal cortex, in the adrenal gland. It plays a pivotal role in regulating sodium and potassium balance, and thus, has significant implications on blood pressure and fluid balance in the body.<br />
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===Function===<br />
Aldosterone acts on the distal tubules and collecting ducts of the nephron (functional unit of the kidney) to:<br />
* '''Increase Sodium Reabsorption''': This leads to water reabsorption, thereby increasing the blood volume and blood pressure.<br />
* '''Increase Potassium Excretion''': To maintain electrolyte balance.<br />
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The secretion of Aldosterone is primarily regulated by the [[Renin-Angiotensin-Aldosterone System]] (RAAS).<br />
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===Clinical Significance===<br />
* '''Hyperaldosteronism''': Excess production of Aldosterone can lead to hypertension and hypokalemia.<br />
* '''Addison's disease''': A deficiency in Aldosterone production can result in low blood pressure and hyperkalemia.<br />
* '''Aldosterone antagonists''': Medications such as spironolactone and eplerenone block the effects of Aldosterone and are used to treat conditions like heart failure and hypertension.<br />
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===See Also===<br />
* [[Adrenal gland]]<br />
* [[Hypertension]]<br />
* [[Potassium homeostasis]]<br />
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==References==<br />
* "Aldosterone and its physiological roles" - [[Journal of Endocrinology]].<br />
* "Clinical aspects of hyperaldosteronism" - [[Endocrine Reviews]].<br />
[[Category:Endocrinology]]<br />
[[Category:Hormones]]</div>Prab