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Alcohol dehydrogenase - Revision history
2026-04-27T06:18:25Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 04:46, 18 February 2025</td>
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<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">== Alcohol dehydrogenase ==</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"><gallery></ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">File:Protein_ADH5_PDB_1m6h.png|Structure of Alcohol Dehydrogenase 5</ins></div></td></tr>
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<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">File:PDB_1jqa_EBI.jpg|Alcohol Dehydrogenase structure from PDB 1JQA</ins></div></td></tr>
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https://wikimd.org/index.php?title=Alcohol_dehydrogenase&diff=6289735&oldid=prev
Prab: CSV import
2025-02-12T03:14:38Z
<p>CSV import</p>
<p><b>New page</b></p><div>= Alcohol dehydrogenase =<br />
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[[File:Protein_ADH5_PDB_1m6h.png|thumb|right|Structure of Alcohol Dehydrogenase]]<br />
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'''Alcohol dehydrogenase''' (ADH) is a group of [[enzymes]] that catalyze the conversion of [[alcohols]] to [[aldehydes]] or [[ketones]] with the reduction of [[NAD+]] to [[NADH]]. These enzymes play a crucial role in the metabolism of alcohols in various organisms, including humans.<br />
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== Structure ==<br />
Alcohol dehydrogenases are typically [[dimeric]] or [[tetrameric]] enzymes, with each subunit containing a [[zinc]] ion that is essential for their catalytic activity. The zinc ion is coordinated by [[cysteine]] residues, as shown in the image [[File:Zinc_interaction_Cysteine.jpg|thumb|right|Zinc interaction with cysteine residues]].<br />
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== Function ==<br />
The primary function of alcohol dehydrogenase is to facilitate the oxidation of alcohols to aldehydes or ketones. This reaction is important in the [[metabolism]] of [[ethanol]] in the liver, where ethanol is converted to [[acetaldehyde]], a process that is crucial for the detoxification of alcohol in the body.<br />
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== Types ==<br />
There are several classes of alcohol dehydrogenases, each with different substrate specificities and tissue distributions. In humans, the most well-known is the class I alcohol dehydrogenase, which is primarily found in the liver.<br />
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== Mechanism ==<br />
The catalytic mechanism of alcohol dehydrogenase involves the transfer of a hydride ion from the alcohol to the NAD+ cofactor, forming NADH. The active site of the enzyme, depicted in [[File:active_site3.jpg|thumb|right|Active site of Alcohol Dehydrogenase]], is where this reaction takes place.<br />
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== Clinical significance ==<br />
Mutations or polymorphisms in alcohol dehydrogenase genes can affect an individual's ability to metabolize alcohol, influencing susceptibility to [[alcoholism]] and [[alcohol-related liver disease]].<br />
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== Related pages ==<br />
* [[Enzyme]]<br />
* [[Metabolism]]<br />
* [[Ethanol]]<br />
* [[NAD+]]<br />
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== Gallery ==<br />
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File:ladh.jpg|Liver alcohol dehydrogenase<br />
File:AlcoholDehydrogenase-1A4U.png|Alcohol dehydrogenase structure<br />
File:PDB_1jqa_EBI.jpg|Crystal structure of alcohol dehydrogenase<br />
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[[Category:Enzymes]]<br />
[[Category:Metabolism]]</div>
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