Aggressive lymphoma - Revision history

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	== Aggressive Lymphoma ==
			{{Infobox medical condition
			\| name = Aggressive lymphoma
			\| image =[[File:Diffuse_large_B_cell_lymphoma_(3)_tonsil.jpg\|250px]]
			\| caption = Micrograph of [[Diffuse large B-cell lymphoma]], a type of aggressive lymphoma. [[H&E stain]].
			\| field = [[Hematology]]
			\| symptoms = [[Lymphadenopathy]], [[fever]], [[night sweats]], [[weight loss]]
			\| complications = [[Tumor lysis syndrome]], [[infection]], [[anemia]]
			\| onset = Variable, often rapid
			\| duration = Variable, can be chronic
			\| types = [[Diffuse large B-cell lymphoma]], [[Burkitt lymphoma]], [[Mantle cell lymphoma]]
			\| causes = Genetic mutations, [[Epstein-Barr virus]], [[HIV]]
			\| risks = [[Immunosuppression]], [[autoimmune disease]], [[family history]]
			\| diagnosis = [[Biopsy]], [[immunohistochemistry]], [[flow cytometry]]
			\| differential = [[Indolent lymphoma]], [[reactive lymphadenopathy]], [[infection]]
			\| prevention = None specific, manage risk factors
			\| treatment = [[Chemotherapy]], [[radiation therapy]], [[stem cell transplant]]
			\| prognosis = Variable, depends on type and stage
			\| frequency = Common
			}}
			== Aggressive Lymphoma ==

	'''Aggressive lymphoma''' refers to a group of fast-growing [[non-Hodgkin lymphoma\|non-Hodgkin lymphomas]] that require prompt diagnosis and treatment. These lymphomas are characterized by rapid proliferation of malignant [[lymphocyte\|lymphocytes]], leading to quickly enlarging [[lymph node\|lymph nodes]] and potential involvement of extranodal sites.		'''Aggressive lymphoma''' refers to a group of fast-growing [[non-Hodgkin lymphoma\|non-Hodgkin lymphomas]] that require prompt diagnosis and treatment. These lymphomas are characterized by rapid proliferation of malignant [[lymphocyte\|lymphocytes]], leading to quickly enlarging [[lymph node\|lymph nodes]] and potential involvement of extranodal sites.

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	[[Category:Lymphoma]]		[[Category:Lymphoma]]
	[[Category:Hematologic neoplasms]]		[[Category:Hematologic neoplasms]]
			<gallery>
			File:Diffuse_large_B_cell_lymphoma_(3)_tonsil.jpg\|Diffuse large B-cell lymphoma in tonsil
			File:Burkitt_lymphoma,_touch_prep,_Wright_stain.jpg\|Burkitt lymphoma, touch prep, Wright stain
			</gallery>

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2025-02-11T22:00:14Z

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== Aggressive Lymphoma ==

'''Aggressive lymphoma''' refers to a group of fast-growing [[non-Hodgkin lymphoma|non-Hodgkin lymphomas]] that require prompt diagnosis and treatment. These lymphomas are characterized by rapid proliferation of malignant [[lymphocyte|lymphocytes]], leading to quickly enlarging [[lymph node|lymph nodes]] and potential involvement of extranodal sites.

== Types ==

Aggressive lymphomas include several subtypes, with the most common being:

=== Diffuse Large B-Cell Lymphoma (DLBCL) ===
[[File:Diffuse_large_B_cell_lymphoma_(3)_tonsil.jpg|thumb|Diffuse large B-cell lymphoma in the tonsil]]
DLBCL is the most prevalent form of aggressive lymphoma, accounting for approximately 30-40% of all cases. It typically presents with rapidly enlarging masses in lymph nodes or extranodal sites such as the [[gastrointestinal tract]], [[central nervous system]], or [[bone marrow]].

=== Burkitt Lymphoma ===
[[File:Burkitt_lymphoma,_touch_prep,_Wright_stain.jpg|thumb|Burkitt lymphoma, touch prep, Wright stain]]
Burkitt lymphoma is a highly aggressive B-cell lymphoma characterized by the translocation of the [[MYC oncogene]]. It is most commonly seen in children and young adults and is associated with [[Epstein-Barr virus]] in endemic forms.

=== Mantle Cell Lymphoma ===
Mantle cell lymphoma is a rare subtype of aggressive lymphoma that often presents with widespread disease, including lymphadenopathy, splenomegaly, and bone marrow involvement. It is characterized by the overexpression of [[cyclin D1]] due to a translocation involving chromosomes 11 and 14.

=== Peripheral T-Cell Lymphoma ===
This is a heterogeneous group of aggressive lymphomas derived from mature T-cells. They often present with systemic symptoms such as fever, weight loss, and night sweats, along with lymphadenopathy and extranodal involvement.

== Diagnosis ==

The diagnosis of aggressive lymphoma typically involves a combination of:

* [[Biopsy]] of affected tissue, often a lymph node, to obtain a histological diagnosis.
* [[Immunohistochemistry]] and flow cytometry to determine the specific subtype of lymphoma.
* [[Cytogenetic]] and molecular studies to identify characteristic genetic abnormalities.

== Treatment ==

Treatment of aggressive lymphoma usually involves:

* [[Chemotherapy]], often with regimens such as [[R-CHOP]] (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone).
* [[Radiation therapy]] in certain cases, particularly for localized disease.
* [[Stem cell transplantation]] for relapsed or refractory cases.

== Prognosis ==

The prognosis for aggressive lymphoma varies depending on the specific subtype, stage at diagnosis, and response to treatment. DLBCL, for example, has a 5-year survival rate of approximately 60-70% with appropriate therapy.

== Related Pages ==
* [[Non-Hodgkin lymphoma]]
* [[Lymphoma]]
* [[Hodgkin lymphoma]]
* [[Leukemia]]

== Gallery ==
<gallery>
File:Diffuse_large_B_cell_lymphoma_(3)_tonsil.jpg|Diffuse large B-cell lymphoma in the tonsil
File:Burkitt_lymphoma,_touch_prep,_Wright_stain.jpg|Burkitt lymphoma, touch prep, Wright stain
</gallery>

[[Category:Lymphoma]]
[[Category:Hematologic neoplasms]]