Deepika vegiraju at 08:37, 14 September 2022

2022-09-14T08:37:02Z

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== '''What is Adapalene?''' ==

* Adapalene ('''Differin''') is a [[retinoid]], used for the [[topical]] treatment of [[acne vulgaris]] in patients 12 years of age and older.

[[File:Adapalene.svg|thumb]]
[[File:Adapalene-3D-balls.png|thumb|'''Adapalene-3D-balls''']]
[[File:Adapalene3D.png|thumb|'''Adapalene3D''']]

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== '''What are the uses of this medicine?''' ==

* Adapalene (Differin) is used for the [[topical]] treatment of [[acne vulgaris]] in patients 12 years of age and older.

== '''How does this medicine work?''' ==

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* Adapalene '''binds to specific retinoic acid nuclear receptors but does not bind to cytosolic receptor protein'''.
* Biochemical and pharmacological profile studies have demonstrated that '''adapalene is a modulator of cellular differentiation, keratinization, and inflammatory processes'''.
* However, the significance of these findings with regard to the mechanism of action of adapalene for the treatment of [[acne]] is unknown.

== '''Who Should Not Use this medicine ?''' ==

This medicine cannot be used in patients who:
* are hypersensitive to adapalene or any of the components in the gel vehicle.

== '''What drug interactions can this medicine cause?''' ==

* No formal drug-drug interaction studies were conducted with Differin.

== '''Is this medicine FDA approved?''' ==

* Adapalene (Differin) is FDA approved on Jun 14, 2012.

== '''How should this medicine be used?''' ==

'''Recommended dosage:'''
* Apply a thin film of Differin Gel, 0.3% to the entire face and any other affected areas of the skin once daily in the evening, after washing gently with a non-medicated soap.
* If therapeutic results are not noticed after 12 weeks of treatment, therapy should be re-evaluated.

'''Administration:'''
* For topical use only. Not for [[ophthalmic]], oral or intravaginal use.
* Avoid application to the areas of skin around eyes, lips, and mucous membranes.
* A mild transitory sensation of warmth or slight [[stinging]] may occur shortly after the application of Differin Gel, 0.3%.
* Patients should be instructed to minimize sun exposure.
* Patients may be instructed to use [[moisturizers]] for relief of dry skin or irritation.

== '''What are the dosage forms and brand names of this medicine?''' ==

This medicine is available in fallowing doasage form:
'''As Differin Gel, 0.3%:''' Each gram of Differin Gel, 0.3% contains 3 mg adapalene in an off-white aqueous gel.

This medicine is available in fallowing brand namesː
* '''Differin'''

=='''What side effects can this medication cause?'''==

The most common side effects of this medicine include:
* dry skin
* skin discomfort
* [[pruritus]]
* [[desquamation]]
* [[sunburn]]

==''' What special precautions should I follow?''' ==

* Avoid exposure to sunlight and [[sunlamps]]. Wear sunscreen when sun exposure cannot be avoided. [[Erythema]], scaling, dryness, and stinging/burning were reported with use of Differin Gel.
* Certain cutaneous signs and symptoms of treatment such as erythema, scaling, dryness, and stinging/burning were reported with use of Differin Gel, 0.3%. Depending upon the severity of these side effects, patients should be instructed to either use a moisturizer, reduce the frequency of application of Differin Gel, 0.3% or discontinue use.
* Avoid contact with the eyes, lips, angles of the nose, and mucous membranes. The product should not be applied to cuts, abrasions, eczematous or sunburned skin.
* Reactions characterized by symptoms such as [[pruritus]], face [[edema]], eyelid edema, and lip swelling, requiring medical treatment have been reported during postmarketing use of adapalene.

== '''What to do in case of emergency/overdose?''' ==

Symptoms of overdosage may include:
* marked redness
* [[scaling]]
* skin discomfort

* [[Chronic]] ingestion of the drug may lead to the same side effects as those associated with excessive oral intake of [[vitamin A]].

== '''Can this medicine be used in pregnancy?''' ==

* [[Retinoids]] may cause fetal harm, when administered to pregnant women.
* There are no adequate and well-controlled studies in pregnant women.
* Differin Gel, 0.3% should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
* The safety and efficacy of Differin Gel, 0.3% in pregnancy has not been established.

=='''Can this medicine be used in children?'''==

* Safety and effectiveness have not been established in pediatric patients below the age of 12.

== '''What are the active and inactive ingredients in this medicine?''' ==

'''Active ingredient:'''
* Adapalene

'''Inactive ingredients:'''
* Carbomer Homopolymer Type C
* Edetate Disodium
* Methylparaben
* Propylene Glycol
* Water
* Sodium Hydroxide
* Hydrochloric Acid
* Poloxamer 124

== '''Who manufactures and distributes this medicine?''' ==

'''Marketed by:'''
[[GALDERMA LABORATORIES]], L.P.
Fort Worth, Texas USA
Made in Canada
GALDERMA is a registered trademark.

== '''What should I know about storage and disposal of this medication?''' ==

* Store at controlled room temperature 68° to 77°F (20° to 25°C) with excursions permitted between 59° to 86°F (15° to 30°C).
* Protect from freezing.

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{{Acne agents}}
{{Retinoid receptor modulators}}
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[[Category:Anti-acne preparations]]
[[Category:Retinoids]]
[[Category:Naphthoic acids]]
[[Category:Adamantanes]]
[[Category:4-Hydroxybiphenyl ethers]]
[[Category:French inventions]]

Adapalene - Revision history

Deepika vegiraju at 08:37, 14 September 2022