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<p><b>New page</b></p><div>[[File:Acrylfentanyl.svg|thumb|Acrylfentanyl.svg]] '''Acrylfentanyl''' is a potent synthetic opioid analgesic that is structurally related to [[fentanyl]]. It is part of the [[fentanyl analogues]] class, which includes various synthetic opioids that mimic the effects of fentanyl. Acrylfentanyl has been associated with numerous cases of overdose and fatalities, particularly in the context of the [[opioid epidemic]].<br />
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==Chemical Structure and Properties==<br />
Acrylfentanyl is chemically known as N-(1-phenethylpiperidin-4-yl)-N-phenylacrylamide. Its molecular formula is C22H26N2O, and it has a molecular weight of 334.46 g/mol. The compound features an acrylamide group attached to the fentanyl core structure, which contributes to its high potency.<br />
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==Pharmacology==<br />
Acrylfentanyl acts as a [[mu-opioid receptor]] agonist, similar to other opioids. It binds to these receptors in the [[central nervous system]], leading to analgesic effects, euphoria, and respiratory depression. The potency of acrylfentanyl is estimated to be several times that of [[morphine]] and similar to that of fentanyl.<br />
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==Medical Use==<br />
Acrylfentanyl has no approved medical use and is not prescribed for any conditions. Its primary use has been in [[recreational drug]] contexts, often as a substitute for or adulterant in other opioids.<br />
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==Legal Status==<br />
Due to its high potential for abuse and lack of medical use, acrylfentanyl is classified as a [[Schedule I controlled substance]] in many countries, including the [[United States]] and several [[European Union]] member states. This classification indicates that it is illegal to manufacture, distribute, or possess acrylfentanyl.<br />
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==Health Risks and Overdose==<br />
The use of acrylfentanyl carries significant health risks, primarily due to its potency and the potential for overdose. Symptoms of overdose include severe respiratory depression, loss of consciousness, and death. The [[antidote]] for opioid overdose, [[naloxone]], can be used to reverse the effects of acrylfentanyl, but multiple doses may be required due to its high potency.<br />
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==Detection and Analysis==<br />
Acrylfentanyl can be detected in biological samples using various analytical techniques, including [[gas chromatography-mass spectrometry]] (GC-MS) and [[liquid chromatography-tandem mass spectrometry]] (LC-MS/MS). These methods are essential for forensic investigations and toxicology screenings.<br />
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==See Also==<br />
* [[Fentanyl]]<br />
* [[Opioid epidemic]]<br />
* [[Synthetic opioids]]<br />
* [[Naloxone]]<br />
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==References==<br />
{{Reflist}}<br />
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==External Links==<br />
{{Commons category|Acrylfentanyl}}<br />
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[[Category:Opioids]]<br />
[[Category:Synthetic opioids]]<br />
[[Category:Analgesics]]<br />
[[Category:Controlled substances]]<br />
[[Category:Drugs with no legal medical use]]<br />
[[Category:Mu-opioid receptor agonists]]<br />
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