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	<id>https://wikimd.com/index.php?action=history&amp;feed=atom&amp;title=ATF5</id>
	<title>ATF5 - Revision history</title>
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	<updated>2026-04-21T13:02:06Z</updated>
	<subtitle>Revision history for this page on the wiki</subtitle>
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	<entry>
		<id>https://wikimd.com/index.php?title=ATF5&amp;diff=6496520&amp;oldid=prev</id>
		<title>Prab: CSV import</title>
		<link rel="alternate" type="text/html" href="https://wikimd.com/index.php?title=ATF5&amp;diff=6496520&amp;oldid=prev"/>
		<updated>2025-03-17T02:55:14Z</updated>

		<summary type="html">&lt;p&gt;CSV import&lt;/p&gt;
&lt;table style=&quot;background-color: #fff; color: #202122;&quot; data-mw=&quot;interface&quot;&gt;
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				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;← Older revision&lt;/td&gt;
				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;Revision as of 02:55, 17 March 2025&lt;/td&gt;
				&lt;/tr&gt;&lt;tr&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot; id=&quot;mw-diff-left-l36&quot;&gt;Line 36:&lt;/td&gt;
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&lt;/table&gt;</summary>
		<author><name>Prab</name></author>
	</entry>
	<entry>
		<id>https://wikimd.com/index.php?title=ATF5&amp;diff=6203964&amp;oldid=prev</id>
		<title>Prab: CSV import</title>
		<link rel="alternate" type="text/html" href="https://wikimd.com/index.php?title=ATF5&amp;diff=6203964&amp;oldid=prev"/>
		<updated>2025-02-10T05:29:51Z</updated>

		<summary type="html">&lt;p&gt;CSV import&lt;/p&gt;
&lt;table style=&quot;background-color: #fff; color: #202122;&quot; data-mw=&quot;interface&quot;&gt;
				&lt;col class=&quot;diff-marker&quot; /&gt;
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				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;← Older revision&lt;/td&gt;
				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;Revision as of 05:29, 10 February 2025&lt;/td&gt;
				&lt;/tr&gt;&lt;tr&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot; id=&quot;mw-diff-left-l35&quot;&gt;Line 35:&lt;/td&gt;
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&lt;tr&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;{{medicine-stub}}&lt;/div&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;{{medicine-stub}}&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
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&lt;/table&gt;</summary>
		<author><name>Prab</name></author>
	</entry>
	<entry>
		<id>https://wikimd.com/index.php?title=ATF5&amp;diff=5378425&amp;oldid=prev</id>
		<title>Prab: CSV import</title>
		<link rel="alternate" type="text/html" href="https://wikimd.com/index.php?title=ATF5&amp;diff=5378425&amp;oldid=prev"/>
		<updated>2024-03-09T21:49:31Z</updated>

		<summary type="html">&lt;p&gt;CSV import&lt;/p&gt;
&lt;p&gt;&lt;b&gt;New page&lt;/b&gt;&lt;/p&gt;&lt;div&gt;&amp;#039;&amp;#039;&amp;#039;ATF5&amp;#039;&amp;#039;&amp;#039; or &amp;#039;&amp;#039;&amp;#039;Activating Transcription Factor 5&amp;#039;&amp;#039;&amp;#039; is a [[protein]] that in humans is encoded by the ATF5 [[gene]]. It is a member of the [[Activating Transcription Factor]]/[[cAMP response element-binding protein]] (ATF/CREB) family of [[transcription factors]].&lt;br /&gt;
&lt;br /&gt;
== Function ==&lt;br /&gt;
ATF5 is a [[transcription factor]] that plays a crucial role in the regulation of [[gene expression]]. It binds to the [[cAMP response element]] (CRE), a sequence of [[DNA]] that is found in the promoter region of many genes. By binding to the CRE, ATF5 can either activate or repress the transcription of the target gene.&lt;br /&gt;
&lt;br /&gt;
ATF5 is also involved in the regulation of [[cell differentiation]] and [[cell survival]]. It has been shown to promote the survival of various types of cells, including [[neurons]] and [[cancer cells]]. In addition, ATF5 is involved in the differentiation of [[glial cells]], a type of cell found in the [[nervous system]].&lt;br /&gt;
&lt;br /&gt;
== Clinical significance ==&lt;br /&gt;
Due to its role in cell survival and differentiation, ATF5 has been implicated in several diseases, including [[cancer]] and [[neurodegenerative diseases]]. In cancer, ATF5 is often overexpressed, leading to increased cell survival and proliferation. In neurodegenerative diseases, ATF5 may play a role in the survival of neurons.&lt;br /&gt;
&lt;br /&gt;
== Research ==&lt;br /&gt;
Research is ongoing to better understand the role of ATF5 in disease and to develop potential therapies targeting this transcription factor. For example, small molecule inhibitors of ATF5 have been developed and are being tested as potential treatments for cancer.&lt;br /&gt;
&lt;br /&gt;
== See also ==&lt;br /&gt;
* [[Activating Transcription Factor]]&lt;br /&gt;
* [[cAMP response element-binding protein]]&lt;br /&gt;
* [[Transcription factor]]&lt;br /&gt;
* [[Gene expression]]&lt;br /&gt;
* [[Cell differentiation]]&lt;br /&gt;
* [[Cell survival]]&lt;br /&gt;
* [[Neurons]]&lt;br /&gt;
* [[Cancer cells]]&lt;br /&gt;
* [[Glial cells]]&lt;br /&gt;
* [[Nervous system]]&lt;br /&gt;
* [[Cancer]]&lt;br /&gt;
* [[Neurodegenerative diseases]]&lt;br /&gt;
&lt;br /&gt;
[[Category:Transcription factors]]&lt;br /&gt;
[[Category:Human proteins]]&lt;br /&gt;
[[Category:Gene expression]]&lt;br /&gt;
[[Category:Cell biology]]&lt;br /&gt;
[[Category:Neuroscience]]&lt;br /&gt;
[[Category:Oncology]]&lt;br /&gt;
[[Category:Neurodegenerative diseases]]&lt;br /&gt;
&lt;br /&gt;
{{medicine-stub}}&lt;/div&gt;</summary>
		<author><name>Prab</name></author>
	</entry>
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