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	<title>AS03 - Revision history</title>
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	<updated>2026-04-20T19:45:52Z</updated>
	<subtitle>Revision history for this page on the wiki</subtitle>
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	<entry>
		<id>https://wikimd.com/index.php?title=AS03&amp;diff=6496506&amp;oldid=prev</id>
		<title>Prab: CSV import</title>
		<link rel="alternate" type="text/html" href="https://wikimd.com/index.php?title=AS03&amp;diff=6496506&amp;oldid=prev"/>
		<updated>2025-03-17T02:54:48Z</updated>

		<summary type="html">&lt;p&gt;CSV import&lt;/p&gt;
&lt;table style=&quot;background-color: #fff; color: #202122;&quot; data-mw=&quot;interface&quot;&gt;
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				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;← Older revision&lt;/td&gt;
				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;Revision as of 02:54, 17 March 2025&lt;/td&gt;
				&lt;/tr&gt;&lt;tr&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot; id=&quot;mw-diff-left-l29&quot;&gt;Line 29:&lt;/td&gt;
&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot;&gt;Line 29:&lt;/td&gt;&lt;/tr&gt;
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&lt;/table&gt;</summary>
		<author><name>Prab</name></author>
	</entry>
	<entry>
		<id>https://wikimd.com/index.php?title=AS03&amp;diff=6203438&amp;oldid=prev</id>
		<title>Prab: CSV import</title>
		<link rel="alternate" type="text/html" href="https://wikimd.com/index.php?title=AS03&amp;diff=6203438&amp;oldid=prev"/>
		<updated>2025-02-10T05:17:29Z</updated>

		<summary type="html">&lt;p&gt;CSV import&lt;/p&gt;
&lt;table style=&quot;background-color: #fff; color: #202122;&quot; data-mw=&quot;interface&quot;&gt;
				&lt;col class=&quot;diff-marker&quot; /&gt;
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				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;← Older revision&lt;/td&gt;
				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;Revision as of 05:17, 10 February 2025&lt;/td&gt;
				&lt;/tr&gt;&lt;tr&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot; id=&quot;mw-diff-left-l28&quot;&gt;Line 28:&lt;/td&gt;
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&lt;tr&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;{{pharmacology-stub}}&lt;/div&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;{{pharmacology-stub}}&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
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&lt;/table&gt;</summary>
		<author><name>Prab</name></author>
	</entry>
	<entry>
		<id>https://wikimd.com/index.php?title=AS03&amp;diff=5373679&amp;oldid=prev</id>
		<title>Prab: CSV import</title>
		<link rel="alternate" type="text/html" href="https://wikimd.com/index.php?title=AS03&amp;diff=5373679&amp;oldid=prev"/>
		<updated>2024-03-08T13:54:52Z</updated>

		<summary type="html">&lt;p&gt;CSV import&lt;/p&gt;
&lt;p&gt;&lt;b&gt;New page&lt;/b&gt;&lt;/p&gt;&lt;div&gt;&amp;#039;&amp;#039;&amp;#039;AS03&amp;#039;&amp;#039;&amp;#039; is an [[adjuvant]] used in [[vaccines]] to enhance the body&amp;#039;s immune response to an [[antigen]]. It is a squalene-based immunologic adjuvant that is used in various vaccines, including those for [[influenza]] and [[hepatitis]]. &lt;br /&gt;
&lt;br /&gt;
== Composition ==&lt;br /&gt;
AS03 contains [[squalene]], [[DL-α-tocopherol]], and [[polysorbate 80]]. Squalene is a naturally occurring oil that is present in humans, animals, and plants. DL-α-tocopherol, also known as vitamin E, is an antioxidant that protects cells from damage. Polysorbate 80 is a surfactant and emulsifier used in foods, cosmetics, and pharmaceuticals.&lt;br /&gt;
&lt;br /&gt;
== Mechanism of Action ==&lt;br /&gt;
The exact mechanism of action of AS03 is not fully understood. However, it is believed to work by stimulating the body&amp;#039;s immune system to produce a stronger and longer-lasting response to the antigen in the vaccine. This is achieved by enhancing the presentation of the antigen to the immune cells, thereby increasing the production of [[antibodies]] and [[T cells]].&lt;br /&gt;
&lt;br /&gt;
== Use in Vaccines ==&lt;br /&gt;
AS03 has been used in several vaccines, including the [[Pandemrix]] vaccine for H1N1 influenza and the [[Fendrix]] vaccine for hepatitis B. It is also being studied for use in vaccines for other diseases, such as [[malaria]] and [[HIV]].&lt;br /&gt;
&lt;br /&gt;
== Safety and Side Effects ==&lt;br /&gt;
AS03 has been shown to be safe and well-tolerated in clinical trials. The most common side effects are mild and temporary, such as pain and swelling at the injection site, fatigue, headache, and muscle pain. However, like all medicines, vaccines with AS03 can cause side effects, although not everybody gets them.&lt;br /&gt;
&lt;br /&gt;
== See Also ==&lt;br /&gt;
* [[Adjuvant]]&lt;br /&gt;
* [[Vaccine]]&lt;br /&gt;
* [[Squalene]]&lt;br /&gt;
* [[DL-α-tocopherol]]&lt;br /&gt;
* [[Polysorbate 80]]&lt;br /&gt;
&lt;br /&gt;
== References ==&lt;br /&gt;
&amp;lt;references /&amp;gt;&lt;br /&gt;
&lt;br /&gt;
[[Category:Immunology]]&lt;br /&gt;
[[Category:Pharmacology]]&lt;br /&gt;
[[Category:Vaccines]]&lt;br /&gt;
&lt;br /&gt;
{{pharmacology-stub}}&lt;/div&gt;</summary>
		<author><name>Prab</name></author>
	</entry>
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