APOBEC3G - Revision history

Prab at 17:28, 18 February 2025

2025-02-18T17:28:38Z

← Older revision		Revision as of 17:28, 18 February 2025
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	==Structure and Function==		==Structure and Function==
	APOBEC3G is a single-stranded DNA cytidine deaminase that catalyzes the deamination of cytidine to uridine. This enzymatic activity results in the introduction of mutations in the viral DNA during reverse transcription, which can lead to the degradation of the viral genome or the production of non-functional viral proteins.		APOBEC3G is a single-stranded DNA cytidine deaminase that catalyzes the deamination of cytidine to uridine. This enzymatic activity results in the introduction of mutations in the viral DNA during reverse transcription, which can lead to the degradation of the viral genome or the production of non-functional viral proteins.

	~~[[File:APOBEC3G_structure.png\|thumb\|right\|300px\|Structure of APOBEC3G bound to DNA.]]~~

	The enzyme is composed of two zinc-coordinating domains, each containing a characteristic [[zinc finger]] motif. These domains are essential for the catalytic activity and substrate binding of APOBEC3G. The N-terminal domain is primarily responsible for RNA binding, while the C-terminal domain contains the active site for deamination.		The enzyme is composed of two zinc-coordinating domains, each containing a characteristic [[zinc finger]] motif. These domains are essential for the catalytic activity and substrate binding of APOBEC3G. The N-terminal domain is primarily responsible for RNA binding, while the C-terminal domain contains the active site for deamination.

Prab: CSV import

2025-02-18T17:27:24Z

CSV import

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-<gallery>
+{{Short description|Enzyme involved in the immune response to viral infections}}
-File:N-terminal_catalytic_domain.jpg|N-terminal catalytic domain of APOBEC3G
+{{DISPLAYTITLE:APOBEC3G}}
-File:Predicted_Mechanism_of_deamination.jpg|Predicted mechanism of deamination by APOBEC3G
-File:Mechanisms_of_encapsidation.png|Mechanisms of encapsidation of APOBEC3G
+==Overview==
-</gallery>
+'''APOBEC3G''' is a member of the [[APOBEC]] family of cytidine deaminases, which are enzymes that play a crucial role in the innate immune response to viral infections. APOBEC3G is particularly known for its ability to inhibit the replication of [[HIV]] and other retroviruses by inducing hypermutation in the viral genome.

Prab: CSV import

2025-02-18T04:03:53Z

CSV import

New page

<gallery>
File:N-terminal_catalytic_domain.jpg|N-terminal catalytic domain of APOBEC3G
File:Predicted_Mechanism_of_deamination.jpg|Predicted mechanism of deamination by APOBEC3G
File:Mechanisms_of_encapsidation.png|Mechanisms of encapsidation of APOBEC3G
</gallery>