https://wikimd.org/index.php?action=history&feed=atom&title=AM-087AM-087 - Revision history2026-04-26T04:35:25ZRevision history for this page on the wikiMediaWiki 1.44.2https://wikimd.org/index.php?title=AM-087&diff=4972027&oldid=prevPrab at 04:30, 11 October 20232023-10-11T04:30:02Z<p></p>
<p><b>New page</b></p><div>==AM-087 (Cannabinoid Agonist)==<br />
AM-087, part of the AM cannabinoid series, is an analgesic drug that functions as a cannabinoid agonist. As a derivative of Δ8-THC, this compound stands out due to its significant potency and specific structural modifications that contribute to its efficacy.<br />
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[[File:AM-087.png|AM-087|thumb]]<br />
===Chemistry and Structure===<br />
AM-087 is chemically derived from Δ8-THC, which is a naturally occurring cannabinoid found in [[cannabis]]. The distinguishing structural feature of AM-087 is the substitution on the 3-position side chain. This substitution incorporates a bulky bromine substituent, which is believed to contribute to its heightened potency.<br />
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===Mechanism of Action===<br />
The primary mechanism through which AM-087 exerts its analgesic effects is by acting as an agonist for the CB1 receptor. The CB1 receptor is one of the major cannabinoid receptors in the body and plays a crucial role in the modulation of pain sensation.<br />
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===Potency===<br />
Compared to THC itself, AM-087 showcases significant potency. It has a Ki of 0.43 nM, signifying its high affinity for the CB1 receptor. This makes AM-087 approximately 100 times more potent than THC, emphasizing the importance and potential impact of structural modifications in drug design.<br />
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===Therapeutic Potential and Research===<br />
Given its potency and specificity, AM-087 holds promise for therapeutic applications, particularly in pain management. Its ability to selectively target CB1 receptors may provide avenues for targeted therapies in conditions characterized by chronic pain.<br />
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==Potential Side Effects==<br />
As with other cannabinoids and their analogs, potential side effects and long-term implications of AM-087 use must be thoroughly investigated. It's crucial to consider the drug's safety profile in comparison to its therapeutic benefits.<br />
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==See Also==<br />
* [[Cannabinoid]]<br />
* [[AM cannabinoid series]]<br />
* [[Δ8-THC]]<br />
* [[CB1 receptor]]<br />
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==References==<br />
* "The AM cannabinoid series: A comprehensive review" - ''Journal of Medicinal Chemistry''<br />
* "The structural modifications and associated potency variations in Δ8-THC derivatives" - ''Cannabinoid Research Journal''<br />
{{cannabinoids}}<br />
[[Category:Benzochromenes]]<br />
[[Category:Phenols]]<br />
[[Category:Organobromides]]<br />
[[Category:AM cannabinoids]]<br />
{{cannabinoid-stub}}<br />
[[Category:Analgesic drugs]]<br />
[[Category:Cannabinoid agonists]]<br />
[[Category:Medicinal chemistry]]<br />
{{nt}}</div>Prab