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	<title>ADAM8 - Revision history</title>
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	<updated>2026-04-06T19:07:17Z</updated>
	<subtitle>Revision history for this page on the wiki</subtitle>
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	<entry>
		<id>https://wikimd.com/index.php?title=ADAM8&amp;diff=6496521&amp;oldid=prev</id>
		<title>Prab: CSV import</title>
		<link rel="alternate" type="text/html" href="https://wikimd.com/index.php?title=ADAM8&amp;diff=6496521&amp;oldid=prev"/>
		<updated>2025-03-17T02:55:14Z</updated>

		<summary type="html">&lt;p&gt;CSV import&lt;/p&gt;
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				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;Revision as of 02:55, 17 March 2025&lt;/td&gt;
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&lt;/table&gt;</summary>
		<author><name>Prab</name></author>
	</entry>
	<entry>
		<id>https://wikimd.com/index.php?title=ADAM8&amp;diff=6202500&amp;oldid=prev</id>
		<title>Prab: CSV import</title>
		<link rel="alternate" type="text/html" href="https://wikimd.com/index.php?title=ADAM8&amp;diff=6202500&amp;oldid=prev"/>
		<updated>2025-02-10T04:56:08Z</updated>

		<summary type="html">&lt;p&gt;CSV import&lt;/p&gt;
&lt;table style=&quot;background-color: #fff; color: #202122;&quot; data-mw=&quot;interface&quot;&gt;
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				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;Revision as of 04:56, 10 February 2025&lt;/td&gt;
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&lt;/table&gt;</summary>
		<author><name>Prab</name></author>
	</entry>
	<entry>
		<id>https://wikimd.com/index.php?title=ADAM8&amp;diff=5378062&amp;oldid=prev</id>
		<title>Prab: CSV import</title>
		<link rel="alternate" type="text/html" href="https://wikimd.com/index.php?title=ADAM8&amp;diff=5378062&amp;oldid=prev"/>
		<updated>2024-03-09T21:20:43Z</updated>

		<summary type="html">&lt;p&gt;CSV import&lt;/p&gt;
&lt;p&gt;&lt;b&gt;New page&lt;/b&gt;&lt;/p&gt;&lt;div&gt;&amp;#039;&amp;#039;&amp;#039;ADAM8&amp;#039;&amp;#039;&amp;#039; (A Disintegrin And Metalloproteinase 8) is a [[protein]] that in humans is encoded by the ADAM8 [[gene]]. This protein belongs to the [[ADAM (protein)|ADAM]] family, which is involved in cell-cell and cell-matrix interactions, including cell adhesion and [[ectodomain]] shedding.&lt;br /&gt;
&lt;br /&gt;
== Function ==&lt;br /&gt;
ADAM8 is a membrane-bound protein that has both protease and adhesion functions. It is involved in the shedding of cell surface proteins, and in cell adhesion and migration. It is also implicated in [[inflammation]], [[arthritis]], and [[cancer]] metastasis.&lt;br /&gt;
&lt;br /&gt;
== Structure ==&lt;br /&gt;
The ADAM8 protein is composed of several domains: a prodomain, a metalloprotease domain, a disintegrin domain, a cysteine-rich domain, an EGF-like domain, a transmembrane domain, and a cytoplasmic domain. The metalloprotease domain is responsible for the protein&amp;#039;s proteolytic activity, while the disintegrin and cysteine-rich domains are involved in cell adhesion.&lt;br /&gt;
&lt;br /&gt;
== Clinical significance ==&lt;br /&gt;
Alterations in the expression of ADAM8 have been associated with several diseases. Overexpression of ADAM8 has been observed in various types of cancers, including [[breast cancer]], [[prostate cancer]], and [[lung cancer]], and is associated with poor prognosis. In addition, ADAM8 has been implicated in inflammatory diseases such as [[rheumatoid arthritis]] and [[asthma]].&lt;br /&gt;
&lt;br /&gt;
== See also ==&lt;br /&gt;
* [[ADAM (protein)|ADAM]]&lt;br /&gt;
* [[Metalloproteinase]]&lt;br /&gt;
* [[Disintegrin]]&lt;br /&gt;
&lt;br /&gt;
== References ==&lt;br /&gt;
&amp;lt;references /&amp;gt;&lt;br /&gt;
&lt;br /&gt;
[[Category:Proteins]]&lt;br /&gt;
[[Category:Genes]]&lt;br /&gt;
[[Category:Cell biology]]&lt;br /&gt;
[[Category:Medical genetics]]&lt;br /&gt;
[[Category:Cancer]]&lt;br /&gt;
[[Category:Inflammation]]&lt;br /&gt;
[[Category:Arthritis]]&lt;br /&gt;
[[Category:Asthma]]&lt;br /&gt;
&lt;br /&gt;
{{Protein-stub}}&lt;br /&gt;
{{medicine-stub}}&lt;/div&gt;</summary>
		<author><name>Prab</name></author>
	</entry>
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