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ACE - Revision history
2026-04-24T17:31:33Z
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<p><b>New page</b></p><div>'''ACE (Angiotensin-converting enzyme)'''<br />
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[[Angiotensin-converting enzyme]] (ACE) is an [[enzyme]] that helps regulate [[blood pressure]]. It is part of the [[renin–angiotensin system]], which is a major target for drugs that lower blood pressure. ACE converts the hormone [[angiotensin I]] to the active vasoconstrictor [[angiotensin II]]. Therefore, ACE indirectly increases blood pressure by causing blood vessels to constrict.<br />
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== Function ==<br />
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ACE is a central component of the [[renin–angiotensin system]] (RAS), which controls blood pressure by regulating the volume of fluids in the body. It converts the hormone [[angiotensin I]] to the active vasoconstrictor [[angiotensin II]]. Therefore, ACE and its inhibitors are of great interest to medicine due to their effect on blood pressure.<br />
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== Clinical significance ==<br />
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ACE inhibitors are widely used as pharmaceutical drugs in the treatment of conditions such as high blood pressure, heart failure, diabetic nephropathy, and type 2 diabetes mellitus. ACE inhibitors inhibit the conversion of [[angiotensin I]] to [[angiotensin II]], and thus lower arteriolar resistance and increase venous capacity.<br />
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== See also ==<br />
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* [[Renin–angiotensin system]]<br />
* [[ACE inhibitor]]<br />
* [[Angiotensin II receptor antagonist]]<br />
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== References ==<br />
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<references /><br />
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[[Category:EC 3.4.15]]<br />
[[Category:Blood pressure]]<br />
[[Category:Enzymes]]<br />
[[Category:Renin–angiotensin system]]<br />
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{{stub}}</div>
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