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'''ABCC9''' is a gene in humans that encodes a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. The protein encoded by this gene is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is thought to form ATP-sensitive potassium channels in cardiac, skeletal, vascular and non-vascular smooth muscle. These channels are known to regulate sleep and to be involved in neurological and cardiovascular diseases.

== Function ==
The [[ABCC9]] gene provides instructions for making a protein that is part of a potassium channel. These channels, which transport positively charged atoms (ions) of potassium into and out of cells, play a key role in a cell's ability to generate and transmit electrical signals.

== Clinical significance ==
Mutations in the [[ABCC9]] gene have been associated with dilated cardiomyopathy 10 (CMD1O) and familial atrial fibrillation.

== See also ==
* [[ATP-binding cassette transporter]]
* [[Dilated cardiomyopathy]]
* [[Familial atrial fibrillation]]

== References ==
<references />

== External links ==
* [https://www.ncbi.nlm.nih.gov/gene/10060 GeneReviews/NCBI/NIH/UW entry on Familial Atrial Fibrillation]

[[Category:Genes]]
[[Category:Human proteins]]
[[Category:ATP-binding cassette transporters]]

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ABCC9 - Revision history

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