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ABCC3 - Revision history
2026-05-11T07:15:50Z
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2025-03-17T02:56:47Z
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<p><b>New page</b></p><div>'''ABCC3''' is a gene that in humans encodes the [[protein]] ABCC3, also known as the multidrug resistance-associated protein 3 (MRP3). This protein is a member of the superfamily of [[ATP-binding cassette (ABC) transporter]] proteins. <br />
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== Function ==<br />
The ABCC3 protein functions as a [[conjugate export pump]] for both [[glucuronide]] and [[sulfate]] conjugates of [[bilirubin]], [[steroid]], and [[xenobiotics]]. It is primarily expressed in the [[liver]] and to a lesser extent in the [[kidney]]. The protein is localized in the [[basolateral membrane]] of [[hepatocyte]]s, where it plays a crucial role in the transport of bile acids and organic anions.<br />
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== Clinical Significance ==<br />
Mutations in the ABCC3 gene have been associated with [[Dubin-Johnson syndrome]], a rare inherited disorder characterized by chronic, benign, intermittent [[jaundice]]. In addition, the ABCC3 protein has been implicated in the development of [[drug resistance]] in cancer cells, as it can transport a wide range of chemotherapeutic agents out of cells.<br />
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== Research ==<br />
Research into the ABCC3 gene and protein is ongoing, with studies investigating its role in drug resistance, liver disease, and other conditions. Understanding the function and regulation of ABCC3 may lead to new therapeutic strategies for treating a variety of diseases.<br />
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== See Also ==<br />
* [[ATP-binding cassette transporter]]<br />
* [[Dubin-Johnson syndrome]]<br />
* [[Drug resistance]]<br />
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[[Category:Human proteins]]<br />
[[Category:ATP-binding cassette transporters]]<br />
[[Category:Genes]]<br />
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{{medicine-stub}}<br />
{{genetics-stub}}</div>
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