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	<title>ABCA1 - Revision history</title>
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	<updated>2026-05-13T12:27:44Z</updated>
	<subtitle>Revision history for this page on the wiki</subtitle>
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	<entry>
		<id>https://wikimd.org/index.php?title=ABCA1&amp;diff=6496424&amp;oldid=prev</id>
		<title>Prab: CSV import</title>
		<link rel="alternate" type="text/html" href="https://wikimd.org/index.php?title=ABCA1&amp;diff=6496424&amp;oldid=prev"/>
		<updated>2025-03-17T02:51:18Z</updated>

		<summary type="html">&lt;p&gt;CSV import&lt;/p&gt;
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				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;Revision as of 02:51, 17 March 2025&lt;/td&gt;
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&lt;/table&gt;</summary>
		<author><name>Prab</name></author>
	</entry>
	<entry>
		<id>https://wikimd.org/index.php?title=ABCA1&amp;diff=6202598&amp;oldid=prev</id>
		<title>Prab: CSV import</title>
		<link rel="alternate" type="text/html" href="https://wikimd.org/index.php?title=ABCA1&amp;diff=6202598&amp;oldid=prev"/>
		<updated>2025-02-10T04:58:49Z</updated>

		<summary type="html">&lt;p&gt;CSV import&lt;/p&gt;
&lt;table style=&quot;background-color: #fff; color: #202122;&quot; data-mw=&quot;interface&quot;&gt;
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				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;Revision as of 04:58, 10 February 2025&lt;/td&gt;
				&lt;/tr&gt;&lt;tr&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot; id=&quot;mw-diff-left-l25&quot;&gt;Line 25:&lt;/td&gt;
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&lt;/table&gt;</summary>
		<author><name>Prab</name></author>
	</entry>
	<entry>
		<id>https://wikimd.org/index.php?title=ABCA1&amp;diff=5297946&amp;oldid=prev</id>
		<title>Prab: CSV import</title>
		<link rel="alternate" type="text/html" href="https://wikimd.org/index.php?title=ABCA1&amp;diff=5297946&amp;oldid=prev"/>
		<updated>2024-02-25T21:10:17Z</updated>

		<summary type="html">&lt;p&gt;CSV import&lt;/p&gt;
&lt;p&gt;&lt;b&gt;New page&lt;/b&gt;&lt;/p&gt;&lt;div&gt;&amp;#039;&amp;#039;&amp;#039;ABCA1&amp;#039;&amp;#039;&amp;#039; (ATP Binding Cassette Subfamily A Member 1) is a protein that in humans is encoded by the ABCA1 gene. It is a member of the ATP-binding cassette (ABC) transporter superfamily. ABCA1 plays a crucial role in [[lipid metabolism]] and is involved in the process of [[reverse cholesterol transport]] (RCT), which is the mechanism by which excess cholesterol is removed from cells and transported to the liver for excretion.&lt;br /&gt;
&lt;br /&gt;
== Function ==&lt;br /&gt;
ABCA1 is a cell membrane protein that exports cholesterol and phospholipids to lipid-poor [[apolipoproteins]], which then form nascent [[high-density lipoprotein]] (HDL) particles. This process is critical for the formation of HDL and the removal of cholesterol from the body. Mutations in the ABCA1 gene can lead to deficiencies in HDL, resulting in an increased risk of [[atherosclerosis]] and [[coronary artery disease]].&lt;br /&gt;
&lt;br /&gt;
== Clinical significance ==&lt;br /&gt;
Mutations in the ABCA1 gene can cause Tangier disease, a rare genetic disorder characterized by a severe reduction in HDL levels and an accumulation of cholesterol in body tissues. Individuals with Tangier disease have an increased risk of developing premature atherosclerosis and coronary artery disease.&lt;br /&gt;
&lt;br /&gt;
== See also ==&lt;br /&gt;
* [[ATP-binding cassette transporter]]&lt;br /&gt;
* [[High-density lipoprotein]]&lt;br /&gt;
* [[Atherosclerosis]]&lt;br /&gt;
* [[Coronary artery disease]]&lt;br /&gt;
* [[Tangier disease]]&lt;br /&gt;
&lt;br /&gt;
== References ==&lt;br /&gt;
&amp;lt;references /&amp;gt;&lt;br /&gt;
&lt;br /&gt;
== External links ==&lt;br /&gt;
* [https://www.ncbi.nlm.nih.gov/gene/19 ABCA1] at the National Center for Biotechnology Information&lt;br /&gt;
&lt;br /&gt;
[[Category:Genes]]&lt;br /&gt;
[[Category:Proteins]]&lt;br /&gt;
[[Category:Lipid metabolism]]&lt;br /&gt;
[[Category:Cardiovascular diseases]]&lt;br /&gt;
{{stub}}&lt;/div&gt;</summary>
		<author><name>Prab</name></author>
	</entry>
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