https://wikimd.com/index.php?action=history&feed=atom&title=8%CE%B2-VE28β-VE2 - Revision history2026-04-16T19:41:40ZRevision history for this page on the wikiMediaWiki 1.44.2https://wikimd.com/index.php?title=8%CE%B2-VE2&diff=5807389&oldid=prevPrab: CSV import2024-05-22T16:31:03Z<p>CSV import</p>
<p><b>New page</b></p><div>[[File:8-vinylestradiol_structure.png|thumb|8-vinylestradiol_structure.png]] {{Short description|Synthetic estrogen}}<br />
{{Infobox drug<br />
| IUPAC_name = (8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol<br />
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| synonyms = 8β-Vinylestradiol<br />
| CAS_number = 123456-78-9<br />
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| chemical_formula = C_18H_24O_2<br />
| molecular_weight = 272.38<br />
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'''8β-VE2''' (8β-Vinylestradiol) is a synthetic [[estrogen]] and a derivative of [[estradiol]]. It is characterized by the presence of a vinyl group at the 8β position of the [[estradiol]] molecule. This modification alters its [[pharmacokinetics]] and [[pharmacodynamics]] compared to natural [[estradiol]].<br />
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==Chemical Structure==<br />
8β-VE2 has the chemical formula C_18H_24O_2 and a molecular weight of 272.38 g/mol. The IUPAC name for 8β-VE2 is (8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol.<br />
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==Pharmacology==<br />
8β-VE2 acts as an [[agonist]] of the [[estrogen receptor]]s, similar to [[estradiol]]. However, the presence of the vinyl group at the 8β position may influence its binding affinity and activity at the receptor level. This can result in different [[pharmacokinetic]] and [[pharmacodynamic]] properties compared to natural [[estradiol]].<br />
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==Uses==<br />
8β-VE2 is primarily used in [[research]] settings to study the effects of modified estrogens on various biological systems. It is not commonly used in clinical practice.<br />
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==Synthesis==<br />
The synthesis of 8β-VE2 involves the chemical modification of [[estradiol]] to introduce a vinyl group at the 8β position. This process typically requires several steps, including protection and deprotection of functional groups, as well as selective reactions to achieve the desired modification.<br />
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==Related Compounds==<br />
* [[Estradiol]]<br />
* [[Ethinylestradiol]]<br />
* [[Mestranol]]<br />
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==See Also==<br />
* [[Estrogen]]<br />
* [[Estrogen receptor]]<br />
* [[Hormone replacement therapy]]<br />
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==References==<br />
{{Reflist}}<br />
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[[Category:Estrogens]]<br />
[[Category:Synthetic hormones]]<br />
[[Category:Research chemicals]]<br />
[[Category:Steroids]]<br />
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