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	~~{{Short description\|A nucleoside derived from uridine}}~~		== 5-Methyluridine ==
	~~{{Use dmy dates\|date~~=~~October 2023}}~~

	~~'''5-Methyluridine''', also known as '''ribothymidine''', is a [[nucleoside]] that is derived from [[uridine]] by the methylation of the 5th carbon of the~~ [[~~uracil]] base~~. ~~It is a component~~ of ~~[[transfer RNA]~~] ~~(tRNA) and plays a role in the [[stability~~]~~] and [[function]] of tRNA molecules.~~		[[File:Ribothymidine_3D_spacefill.png\|thumb\|right\|3D space-filling model of 5-Methyluridine]]

	~~==Structure==~~		'''5-Methyluridine''', also known as '''ribothymidine''', is a modified nucleoside that is found in [[transfer RNA]] (tRNA). It is a derivative of the nucleoside [[uridine]], where a methyl group is added to the 5th carbon of the uracil ring, resulting in the formation of thymine. This modification is important for the stability and function of tRNA molecules.
	5-Methyluridine ~~consists of~~ a [[~~ribose~~]] ~~sugar attached to a [[thymine]] base~~. ~~The ribose~~ is a ~~five-carbon sugar that is part~~ of the [[~~RNA~~]] ~~backbone~~, ~~and the thymine is~~ a ~~[[pyrimidine]] base that~~ is ~~methylated at~~ the 5th carbon ~~position~~. This ~~methylation distinguishes it from [[uridine]], which has a [[uracil]] base~~.

	==~~Function~~==		== Structure ==
	In [[tRNA]], 5-methyluridine is often found in the [[T_C loop]], a region important for the proper folding and function of tRNA molecules. The presence of the methyl group in 5-methyluridine contributes to the [[hydrophobic]] interactions and [[stacking]] interactions that stabilize the tRNA structure.

	~~==Biosynthesis==~~		5-Methyluridine consists of a [[ribose]] sugar attached to a thymine base. The ribose is a five-carbon sugar that is part of the [[RNA]] backbone, and the thymine base is a pyrimidine derivative. The methyl group at the 5th position of the uracil ring distinguishes 5-methyluridine from uridine.
	5-Methyluridine ~~is synthesized in cells by the methylation~~ of ~~uridine residues in tRNA. This process is catalyzed by specific~~ [[~~methyltransferase~~]] ~~enzymes~~ that ~~transfer a methyl group from~~ [[~~S-adenosylmethionine~~]] to the ~~uracil~~ base of uridine.

	==~~Role in RNA~~==		== Function ==
	In ~~addition to its role in~~ tRNA, 5-methyluridine ~~can~~ also ~~be found~~ in ~~other types~~ of ~~RNA, where it may influence~~ the [[~~secondary structure~~]] ~~and~~ [[~~function~~]] ~~of the RNA molecule. Its presence can affect the~~ [[~~thermal stability~~]] and [[~~base pairing~~]] ~~properties~~ of ~~RNA~~.
			In tRNA, 5-methyluridine plays a crucial role in maintaining the correct structure and function of the molecule. The presence of the methyl group enhances the stability of the tRNA by increasing the hydrophobic interactions within the molecule. This modification is also involved in the proper folding of tRNA and in the accurate recognition of the tRNA by [[aminoacyl-tRNA synthetase]] enzymes during protein synthesis.

			== Biosynthesis ==

			The biosynthesis of 5-methyluridine in tRNA involves the methylation of uridine residues. This process is catalyzed by specific [[methyltransferase]] enzymes that transfer a methyl group from [[S-adenosylmethionine]] (SAM) to the uracil base in tRNA. The methylation occurs post-transcriptionally, meaning it takes place after the tRNA has been synthesized.

			== Importance in Biology ==

			5-Methyluridine is one of many modified nucleosides found in tRNA, and these modifications are critical for the proper functioning of the [[translation (biology)\|translation]] process. The modifications help in the stabilization of the tRNA structure, enhance the accuracy of codon-anticodon pairing, and prevent errors during protein synthesis.

			== Related pages ==

	~~==Related pages==~~
	* [[Uridine]]		* [[Uridine]]
	* [[Thymine]]		* [[Thymine]]
			* [[Transfer RNA]]
	* [[Ribose]]		* [[Ribose]]
	* [[Transfer RNA]]
	* [[Methylation]]		* [[Methylation]]

	~~==Gallery==~~
	~~<gallery>~~
	~~File:Ribothymidine_3D_spacefill.png\|3D space-filling model of ribothymidine~~
	~~</gallery>~~

	[[Category:Nucleosides]]		[[Category:Nucleosides]]
	[[Category:RNA]]		[[Category:RNA]]

Prab: CSV import

2025-02-11T21:21:12Z

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{{Short description|A nucleoside derived from uridine}}
{{Use dmy dates|date=October 2023}}

'''5-Methyluridine''', also known as '''ribothymidine''', is a [[nucleoside]] that is derived from [[uridine]] by the methylation of the 5th carbon of the [[uracil]] base. It is a component of [[transfer RNA]] (tRNA) and plays a role in the [[stability]] and [[function]] of tRNA molecules.

==Structure==
5-Methyluridine consists of a [[ribose]] sugar attached to a [[thymine]] base. The ribose is a five-carbon sugar that is part of the [[RNA]] backbone, and the thymine is a [[pyrimidine]] base that is methylated at the 5th carbon position. This methylation distinguishes it from [[uridine]], which has a [[uracil]] base.

==Function==
In [[tRNA]], 5-methyluridine is often found in the [[T_C loop]], a region important for the proper folding and function of tRNA molecules. The presence of the methyl group in 5-methyluridine contributes to the [[hydrophobic]] interactions and [[stacking]] interactions that stabilize the tRNA structure.

==Biosynthesis==
5-Methyluridine is synthesized in cells by the methylation of uridine residues in tRNA. This process is catalyzed by specific [[methyltransferase]] enzymes that transfer a methyl group from [[S-adenosylmethionine]] to the uracil base of uridine.

==Role in RNA==
In addition to its role in tRNA, 5-methyluridine can also be found in other types of RNA, where it may influence the [[secondary structure]] and [[function]] of the RNA molecule. Its presence can affect the [[thermal stability]] and [[base pairing]] properties of RNA.

==Related pages==
* [[Uridine]]
* [[Thymine]]
* [[Ribose]]
* [[Transfer RNA]]
* [[Methylation]]

==Gallery==
<gallery>
File:Ribothymidine_3D_spacefill.png|3D space-filling model of ribothymidine
</gallery>

[[Category:Nucleosides]]
[[Category:RNA]]

5-Methyluridine - Revision history

Prab: CSV import

Prab: CSV import