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<p><b>New page</b></p><div>[[File:Rational_harm_assessment_of_drugs_radar_plot.svg|Rational harm assessment of drugs radar plot|thumb]] [[File:Metabolism_4-MTA.jpg|Metabolism 4-MTA|thumb|left]] '''4-Methylthioamphetamine''' ('''4-MTA'''), also known by its street name '''"Flatliner"''', is a [[psychoactive drug]] and [[research chemical]] belonging to the [[amphetamine]] class. It is known for its [[serotonin]] releasing properties, with lesser effects on [[dopamine]] and [[norepinephrine]] release. 4-MTA has been associated with a number of serious adverse effects and fatalities, leading to its classification as a [[controlled substance]] in several countries.<br />
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==Chemistry==<br />
4-Methylthioamphetamine is a synthetic compound structurally related to [[amphetamine]], differing by the addition of a [[methylthio]] group to the alpha carbon. This modification significantly alters its pharmacological profile, making it a potent [[serotonin]] releaser. The chemical formula for 4-MTA is C_10H_15NS.<br />
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==Pharmacology==<br />
The primary mechanism of action of 4-MTA involves the release of serotonin from [[neuronal]] stores, leading to increased concentrations of serotonin in the [[synaptic cleft]]. Unlike other amphetamines, 4-MTA has a higher selectivity for serotonin release, with relatively minor effects on dopamine and norepinephrine. This results in a profile of effects that is markedly different from more traditional stimulants like [[methamphetamine]] or [[MDMA]].<br />
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==Effects==<br />
The effects of 4-MTA can include [[euphoria]], increased empathy, and heightened sensory perception. However, due to its potent serotonin-releasing capabilities, it also poses significant risks of [[serotonin syndrome]], a potentially life-threatening condition characterized by high body temperature, agitation, increased reflexes, tremor, sweating, dilated pupils, and diarrhea.<br />
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==Risks and Adverse Effects==<br />
The use of 4-MTA has been linked to several serious adverse effects, including hyperthermia, cardiovascular complications, seizures, and death. The risk of serotonin syndrome is particularly high, especially when combined with other serotonergic agents. Its safety profile is poorly understood, given the lack of comprehensive clinical studies.<br />
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==Legal Status==<br />
Due to its potential for abuse and serious health risks, 4-MTA has been made illegal in many countries. It is often listed as a [[Schedule I]] or equivalent substance, indicating a high potential for abuse with no accepted medical use.<br />
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==See Also==<br />
* [[Amphetamine]]<br />
* [[MDMA]]<br />
* [[Serotonin syndrome]]<br />
* [[Controlled Substances Act]]<br />
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[[Category:Psychoactive drugs]]<br />
[[Category:Amphetamines]]<br />
[[Category:Serotonin releasing agents]]<br />
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