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	~~{{Short description\|Metabolite of THC}}~~
	{{DISPLAYTITLE:3'-Hydroxy-THC}}		{{DISPLAYTITLE:3'-Hydroxy-THC}}

	~~'''~~3'-Hydroxy-THC''' (3'-OH-THC) is a [[metabolite]] of [[tetrahydrocannabinol]] (THC), the primary psychoactive component of [[cannabis]]. It is formed in the body through the process of [[hydroxylation]], which is a part of the [[metabolism]] of THC.		== 3'-Hydroxy-THC ==

	==Chemical structure==		[[File:3'-OH-THC_structure.png\|thumb\|right\|Chemical structure of 3'-Hydroxy-THC]]
	3'-Hydroxy-THC ~~is a [[hydroxylated~~]] derivative of THC. The hydroxyl group is added to the third carbon of the pentyl side chain of the THC molecule. This modification can affect the [[pharmacokinetics]] and [[pharmacodynamics]] of the compound.

	~~==Pharmacology==~~		'''3'-Hydroxy-THC''' (3'-OH-THC) is a [[metabolite]] of [[tetrahydrocannabinol]] (THC), the primary psychoactive component of [[cannabis]]. It is formed in the body through the process of [[hydroxylation]], where an [[enzyme]] adds a hydroxyl group (-OH) to the 3' position of the THC molecule.
	3'-Hydroxy-THC is ~~known to have some~~ [[~~psychoactive~~]] ~~effects, although it is generally considered to be less potent than THC itself. The presence~~ of ~~the hydroxyl group can influence the compound's ability to cross the~~ [[~~blood-brain barrier~~]] ~~and interact with~~ [[~~cannabinoid receptors~~]] in the [[~~central nervous system~~]].

	==~~Metabolism~~==		== Chemical Structure ==
	The metabolism of THC involves several steps, with 3'-Hydroxy-THC being one of the intermediate metabolites. THC is initially metabolized by the [[cytochrome P450]] enzyme system in the [[liver]], leading to the formation of 11-hydroxy-THC and subsequently 3'-Hydroxy-THC. These metabolites are further processed into more polar compounds that are excreted from the body.

	==~~Detection in biological samples~~==		3'-Hydroxy-THC is a [[cannabinoid]] with a chemical structure similar to that of THC. The addition of the hydroxyl group at the 3' position alters its [[pharmacokinetics]] and [[pharmacodynamics]], potentially affecting its interaction with the [[endocannabinoid system]].
	3'-Hydroxy-THC ~~can be detected~~ in various ~~biological samples,~~ such as [[~~blood~~]], [[~~urine~~]], and [[~~hair~~]], ~~using techniques like~~ [[~~gas chromatography~~-~~mass spectrometry~~]] ~~(GC~~-~~MS) or~~ [[~~liquid chromatography-tandem mass spectrometry~~]] ~~(LC-MS/MS)~~. ~~The presence~~ of ~~this metabolite~~ can be used to ~~confirm recent~~ cannabis use.
			== Pharmacology ==

			3'-Hydroxy-THC is known to interact with the [[cannabinoid receptor]]s, primarily [[CB1 receptor\|CB1]] and [[CB2 receptor\|CB2]]. These receptors are part of the [[endocannabinoid system]], which plays a role in regulating various physiological processes such as [[pain]], [[appetite]], and [[mood]].

			=== Metabolism ===

			The metabolism of THC to 3'-Hydroxy-THC occurs primarily in the [[liver]] through the action of [[cytochrome P450]] enzymes. This metabolic pathway is part of the body's mechanism to make THC more water-soluble, facilitating its excretion.

			=== Effects ===

			The specific effects of 3'-Hydroxy-THC are not as well-studied as those of THC itself. However, it is believed to contribute to the overall [[psychoactive]] and [[therapeutic]] effects of cannabis consumption. The presence of the hydroxyl group may influence its [[binding affinity]] to cannabinoid receptors and its [[half-life]] in the body.

			== Clinical Significance ==

			Understanding the role of 3'-Hydroxy-THC in the body is important for [[toxicology]] and [[drug testing]]. It is one of the metabolites that can be detected in [[urine]] and [[blood]] tests used to determine cannabis use.

			== Related Pages ==

	~~==Related pages==~~
	* [[Tetrahydrocannabinol]]		* [[Tetrahydrocannabinol]]
			* [[Cannabinoid receptor]]
			* [[Endocannabinoid system]]
	* [[Cannabis (drug)]]		* [[Cannabis (drug)]]
	* [[Cannabinoid receptor]]
	* [[Metabolism of THC]]

	~~==Gallery==~~
	~~<gallery>~~
	~~File:3'-OH-THC_structure.png\|Chemical structure of 3'-Hydroxy-THC~~
	~~</gallery>~~

	[[Category:Cannabinoids]]		[[Category:Cannabinoids]]
	[[Category:Metabolites]]		[[Category:Metabolites]]

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2025-02-11T20:11:12Z

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{{Short description|Metabolite of THC}}
{{DISPLAYTITLE:3'-Hydroxy-THC}}

'''3'-Hydroxy-THC''' (3'-OH-THC) is a [[metabolite]] of [[tetrahydrocannabinol]] (THC), the primary psychoactive component of [[cannabis]]. It is formed in the body through the process of [[hydroxylation]], which is a part of the [[metabolism]] of THC.

==Chemical structure==
3'-Hydroxy-THC is a [[hydroxylated]] derivative of THC. The hydroxyl group is added to the third carbon of the pentyl side chain of the THC molecule. This modification can affect the [[pharmacokinetics]] and [[pharmacodynamics]] of the compound.

==Pharmacology==
3'-Hydroxy-THC is known to have some [[psychoactive]] effects, although it is generally considered to be less potent than THC itself. The presence of the hydroxyl group can influence the compound's ability to cross the [[blood-brain barrier]] and interact with [[cannabinoid receptors]] in the [[central nervous system]].

==Metabolism==
The metabolism of THC involves several steps, with 3'-Hydroxy-THC being one of the intermediate metabolites. THC is initially metabolized by the [[cytochrome P450]] enzyme system in the [[liver]], leading to the formation of 11-hydroxy-THC and subsequently 3'-Hydroxy-THC. These metabolites are further processed into more polar compounds that are excreted from the body.

==Detection in biological samples==
3'-Hydroxy-THC can be detected in various biological samples, such as [[blood]], [[urine]], and [[hair]], using techniques like [[gas chromatography-mass spectrometry]] (GC-MS) or [[liquid chromatography-tandem mass spectrometry]] (LC-MS/MS). The presence of this metabolite can be used to confirm recent cannabis use.

==Related pages==
* [[Tetrahydrocannabinol]]
* [[Cannabis (drug)]]
* [[Cannabinoid receptor]]
* [[Metabolism of THC]]

==Gallery==
<gallery>
File:3'-OH-THC_structure.png|Chemical structure of 3'-Hydroxy-THC
</gallery>

[[Category:Cannabinoids]]
[[Category:Metabolites]]

3'-Hydroxy-THC - Revision history

Prab: CSV import

Prab: CSV import