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11-Hydroxycannabinol - Revision history
2026-04-24T06:00:32Z
Revision history for this page on the wiki
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2025-02-16T05:20:49Z
<p>CSV import</p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 05:20, 16 February 2025</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l1">Line 1:</td>
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">{{Short description|A metabolite of THC}}</del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{DISPLAYTITLE:11-Hydroxycannabinol}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{DISPLAYTITLE:11-Hydroxycannabinol}}</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">'''</del>11-Hydroxycannabinol<del style="font-weight: bold; text-decoration: none;">''' </del>(11-OH-CBN) is a [[cannabinoid]] metabolite that is formed in the body after the consumption of [[tetrahydrocannabinol]] (THC), the primary psychoactive component of <del style="font-weight: bold; text-decoration: none;">[[</del>cannabis<del style="font-weight: bold; text-decoration: none;">]]. It is one of the many metabolites that result from the metabolic processing of THC in the [[liver]]</del>.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">== 11-Hydroxycannabinol ==</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[[File:11-OH-CBN_structure.png|thumb|right|Chemical structure of 11-Hydroxycannabinol]]</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>11-Hydroxycannabinol (11-OH-CBN) is a [[cannabinoid]] metabolite that is formed in the body after the consumption <ins style="font-weight: bold; text-decoration: none;">of [[cannabis]]. It is a hydroxylated form of [[cannabinol]] (CBN), which itself is a degradation product </ins>of [[tetrahydrocannabinol]] (THC), the primary psychoactive component of cannabis.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>==Chemical <del style="font-weight: bold; text-decoration: none;">structure and properties</del>==</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>== Chemical <ins style="font-weight: bold; text-decoration: none;">Structure </ins>==</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>11-Hydroxycannabinol is <del style="font-weight: bold; text-decoration: none;">a hydroxylated form of [[cannabinol]] (CBN). The </del>addition of a hydroxyl group (-OH) <del style="font-weight: bold; text-decoration: none;">to </del>the 11th carbon position of the CBN molecule <del style="font-weight: bold; text-decoration: none;">results in the formation of 11-OH-CBN</del>. This <del style="font-weight: bold; text-decoration: none;">structural </del>modification <del style="font-weight: bold; text-decoration: none;">can influence </del>the compound<del style="font-weight: bold; text-decoration: none;">'s [[pharmacokinetics]] and [[pharmacodynamics]]</del>.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>11-Hydroxycannabinol is <ins style="font-weight: bold; text-decoration: none;">characterized by the </ins>addition of a hydroxyl group (-OH) <ins style="font-weight: bold; text-decoration: none;">at </ins>the 11th carbon position of the CBN molecule. This modification <ins style="font-weight: bold; text-decoration: none;">alters the chemical properties and biological activity of </ins>the compound <ins style="font-weight: bold; text-decoration: none;">compared to its parent molecule, CBN</ins>.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>==<del style="font-weight: bold; text-decoration: none;">Metabolism</del>==</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>== <ins style="font-weight: bold; text-decoration: none;">Pharmacology </ins>==</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">When THC </del>is <del style="font-weight: bold; text-decoration: none;">consumed, it is metabolized by </del>the <del style="font-weight: bold; text-decoration: none;">liver into various metabolites</del>, <del style="font-weight: bold; text-decoration: none;">including 11-hydroxy-THC </del>and <del style="font-weight: bold; text-decoration: none;">11-hydroxycannabinol. The enzyme </del>[[<del style="font-weight: bold; text-decoration: none;">cytochrome P450</del>]] <del style="font-weight: bold; text-decoration: none;">plays a significant role in this metabolic process</del>. <del style="font-weight: bold; text-decoration: none;">11-Hydroxycannabinol is further metabolized into other compounds before being excreted from the body</del>.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">11-Hydroxycannabinol </ins>is <ins style="font-weight: bold; text-decoration: none;">known to interact with </ins>the <ins style="font-weight: bold; text-decoration: none;">[[endocannabinoid system]]</ins>, <ins style="font-weight: bold; text-decoration: none;">specifically binding to [[cannabinoid receptors]] such as [[CB1 receptor|CB1]] </ins>and [[<ins style="font-weight: bold; text-decoration: none;">CB2 receptor|CB2</ins>]]. <ins style="font-weight: bold; text-decoration: none;">These interactions can influence various physiological processes, including mood, appetite, and pain perception</ins>.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>==<del style="font-weight: bold; text-decoration: none;">Pharmacology</del>==</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>==<ins style="font-weight: bold; text-decoration: none;">= Metabolism =</ins>==</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">The pharmacological effects of 11-hydroxycannabinol are not as well-studied as those of THC or </del>11-<del style="font-weight: bold; text-decoration: none;">hydroxy-THC. However, it </del>is <del style="font-weight: bold; text-decoration: none;">known that hydroxylated metabolites of cannabinoids can have different affinities for </del>[[<del style="font-weight: bold; text-decoration: none;">cannabinoid receptors</del>]] <del style="font-weight: bold; text-decoration: none;">such as </del>[[<del style="font-weight: bold; text-decoration: none;">CB1 receptor|CB1</del>]] <del style="font-weight: bold; text-decoration: none;">and </del>[[<del style="font-weight: bold; text-decoration: none;">CB2 receptor|CB2</del>]]<del style="font-weight: bold; text-decoration: none;">. These interactions can influence the psychoactive and physiological effects experienced by the user</del>.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">In the human body, </ins>11-<ins style="font-weight: bold; text-decoration: none;">Hydroxycannabinol </ins>is <ins style="font-weight: bold; text-decoration: none;">produced primarily in the </ins>[[<ins style="font-weight: bold; text-decoration: none;">liver</ins>]] <ins style="font-weight: bold; text-decoration: none;">through the action of </ins>[[<ins style="font-weight: bold; text-decoration: none;">cytochrome P450</ins>]] <ins style="font-weight: bold; text-decoration: none;">enzymes on CBN. This metabolic pathway is similar to the conversion of THC to </ins>[[<ins style="font-weight: bold; text-decoration: none;">11-Hydroxy-THC</ins>]]<ins style="font-weight: bold; text-decoration: none;">, another active metabolite</ins>.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>==<del style="font-weight: bold; text-decoration: none;">Detection in biological samples</del>==</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>== <ins style="font-weight: bold; text-decoration: none;">Biological Effects </ins>==</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>11-Hydroxycannabinol <del style="font-weight: bold; text-decoration: none;">can be detected in biological samples such </del>as <del style="font-weight: bold; text-decoration: none;">[[blood]] and [[urine]] using various analytical techniques</del>. <del style="font-weight: bold; text-decoration: none;">These techniques are often employed in [[toxicology]] </del>and <del style="font-weight: bold; text-decoration: none;">[[forensic science]] </del>to <del style="font-weight: bold; text-decoration: none;">determine cannabis use</del>.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">The biological effects of </ins>11-Hydroxycannabinol <ins style="font-weight: bold; text-decoration: none;">are not as well-studied </ins>as <ins style="font-weight: bold; text-decoration: none;">those of THC or CBN. However, it is believed to have a lower psychoactive potency compared to THC</ins>. <ins style="font-weight: bold; text-decoration: none;">Its effects on the body may include mild sedation </ins>and <ins style="font-weight: bold; text-decoration: none;">analgesia, but further research is needed </ins>to <ins style="font-weight: bold; text-decoration: none;">fully understand its pharmacological profile</ins>.</div></td></tr>
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>==Related <del style="font-weight: bold; text-decoration: none;">pages</del>==</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>== Related <ins style="font-weight: bold; text-decoration: none;">Compounds </ins>==</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>* [[<del style="font-weight: bold; text-decoration: none;">Cannabinoid</del>]]</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>* [[<ins style="font-weight: bold; text-decoration: none;">Cannabinol</ins>]] <ins style="font-weight: bold; text-decoration: none;">(CBN)</ins></div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>* [[Tetrahydrocannabinol]]</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>* [[Tetrahydrocannabinol]] <ins style="font-weight: bold; text-decoration: none;">(THC)</ins></div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">* [[Cannabinol]]</del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* [[11-Hydroxy-THC]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* [[11-Hydroxy-THC]]</div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">* [[Cannabidiol]] (CBD)</ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>==<del style="font-weight: bold; text-decoration: none;">Gallery</del>==</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>== <ins style="font-weight: bold; text-decoration: none;">Related Pages </ins>==</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"><gallery></del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">* [[Cannabinoid]]</ins></div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">File:11-OH-CBN_structure.png|Chemical structure of 11-Hydroxycannabinol</del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">* [[Endocannabinoid system]]</ins></div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"></gallery></del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">* [[Cannabis]]</ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category:Cannabinoids]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category:Cannabinoids]]</div></td></tr>
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https://wikimd.com/index.php?title=11-Hydroxycannabinol&diff=6288494&oldid=prev
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2025-02-11T20:38:45Z
<p>CSV import</p>
<p><b>New page</b></p><div>{{Short description|A metabolite of THC}}<br />
{{DISPLAYTITLE:11-Hydroxycannabinol}}<br />
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'''11-Hydroxycannabinol''' (11-OH-CBN) is a [[cannabinoid]] metabolite that is formed in the body after the consumption of [[tetrahydrocannabinol]] (THC), the primary psychoactive component of [[cannabis]]. It is one of the many metabolites that result from the metabolic processing of THC in the [[liver]].<br />
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==Chemical structure and properties==<br />
11-Hydroxycannabinol is a hydroxylated form of [[cannabinol]] (CBN). The addition of a hydroxyl group (-OH) to the 11th carbon position of the CBN molecule results in the formation of 11-OH-CBN. This structural modification can influence the compound's [[pharmacokinetics]] and [[pharmacodynamics]].<br />
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==Metabolism==<br />
When THC is consumed, it is metabolized by the liver into various metabolites, including 11-hydroxy-THC and 11-hydroxycannabinol. The enzyme [[cytochrome P450]] plays a significant role in this metabolic process. 11-Hydroxycannabinol is further metabolized into other compounds before being excreted from the body.<br />
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==Pharmacology==<br />
The pharmacological effects of 11-hydroxycannabinol are not as well-studied as those of THC or 11-hydroxy-THC. However, it is known that hydroxylated metabolites of cannabinoids can have different affinities for [[cannabinoid receptors]] such as [[CB1 receptor|CB1]] and [[CB2 receptor|CB2]]. These interactions can influence the psychoactive and physiological effects experienced by the user.<br />
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==Detection in biological samples==<br />
11-Hydroxycannabinol can be detected in biological samples such as [[blood]] and [[urine]] using various analytical techniques. These techniques are often employed in [[toxicology]] and [[forensic science]] to determine cannabis use.<br />
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==Related pages==<br />
* [[Cannabinoid]]<br />
* [[Tetrahydrocannabinol]]<br />
* [[Cannabinol]]<br />
* [[11-Hydroxy-THC]]<br />
<br />
==Gallery==<br />
<gallery><br />
File:11-OH-CBN_structure.png|Chemical structure of 11-Hydroxycannabinol<br />
</gallery><br />
<br />
[[Category:Cannabinoids]]</div>
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