10-Formyltetrahydrofolate - Revision history

Prab at 10:20, 26 February 2025

2025-02-26T10:20:05Z

← Older revision		Revision as of 10:20, 26 February 2025
Line 1:		Line 1:
	~~== 10-Formyltetrahydrofolate ==~~

	[[File:10-Formyltetrahydrofolate-3D-spacefill.png\|thumb\|right\|3D space-filling model of 10-Formyltetrahydrofolate]]		[[File:10-Formyltetrahydrofolate-3D-spacefill.png\|thumb\|right\|3D space-filling model of 10-Formyltetrahydrofolate]]
			[[File:10-formyl-tetrahydrofolic acid.svg\|10-formyl-tetrahydrofolic acid\|thumb]]
	'''10-Formyltetrahydrofolate''' is a formyl derivative of [[tetrahydrofolate]], a coenzyme involved in the transfer of one-carbon units in various metabolic reactions. It plays a crucial role in the [[folate metabolism]] and is essential for the synthesis of [[purines]], which are necessary for [[DNA]] and [[RNA]] synthesis.		'''10-Formyltetrahydrofolate''' is a formyl derivative of [[tetrahydrofolate]], a coenzyme involved in the transfer of one-carbon units in various metabolic reactions. It plays a crucial role in the [[folate metabolism]] and is essential for the synthesis of [[purines]], which are necessary for [[DNA]] and [[RNA]] synthesis.

Line 22:		Line 20:
	* [[Purine synthesis]]		* [[Purine synthesis]]
	* [[One-carbon metabolism]]		* [[One-carbon metabolism]]
			{{pharmacology-stub}}
	[[Category:Biochemistry]]		[[Category:Biochemistry]]
	[[Category:Coenzymes]]		[[Category:Coenzymes]]
	[[Category:Folate]]		[[Category:Folate]]
	~~== 10-Formyltetrahydrofolate ==~~
	~~<gallery>~~
	~~File:10-Formyltetrahydrofolate-3D-spacefill.png\|3D spacefill model of 10-Formyltetrahydrofolate~~
	~~</gallery>~~

Prab: CSV import

2025-02-16T21:57:35Z

CSV import

← Older revision		Revision as of 21:57, 16 February 2025
Line 26:		Line 26:
	[[Category:Coenzymes]]		[[Category:Coenzymes]]
	[[Category:Folate]]		[[Category:Folate]]
			== 10-Formyltetrahydrofolate ==
			<gallery>
			File:10-Formyltetrahydrofolate-3D-spacefill.png\|3D spacefill model of 10-Formyltetrahydrofolate
			</gallery>

Prab: CSV import

2025-02-11T20:33:19Z

CSV import

New page

== 10-Formyltetrahydrofolate ==

[[File:10-Formyltetrahydrofolate-3D-spacefill.png|thumb|right|3D space-filling model of 10-Formyltetrahydrofolate]]

'''10-Formyltetrahydrofolate''' is a formyl derivative of [[tetrahydrofolate]], a coenzyme involved in the transfer of one-carbon units in various metabolic reactions. It plays a crucial role in the [[folate metabolism]] and is essential for the synthesis of [[purines]], which are necessary for [[DNA]] and [[RNA]] synthesis.

== Structure ==
10-Formyltetrahydrofolate is a formylated form of tetrahydrofolate, where a formyl group is attached to the N10 position of the pteridine ring. This modification allows it to participate in one-carbon transfer reactions, which are vital for cellular metabolism.

== Function ==
In the cell, 10-formyltetrahydrofolate serves as a donor of formyl groups in the synthesis of purine nucleotides. It is involved in the conversion of [[inosine monophosphate]] (IMP) to [[adenosine monophosphate]] (AMP) and [[guanosine monophosphate]] (GMP), which are precursors for [[DNA]] and [[RNA]] synthesis.

== Metabolic Pathway ==
10-Formyltetrahydrofolate is generated from [[tetrahydrofolate]] through the action of the enzyme [[formyltransferase]]. It can also be interconverted with other one-carbon substituted forms of tetrahydrofolate, such as [[5,10-methenyltetrahydrofolate]] and [[5,10-methylenetetrahydrofolate]], depending on the cellular needs.

== Clinical Significance ==
Deficiencies in folate metabolism, including the availability of 10-formyltetrahydrofolate, can lead to [[megaloblastic anemia]] and other health issues. Adequate levels of folate and its derivatives are crucial during periods of rapid cell division and growth, such as during [[pregnancy]] and [[infancy]].

== Related Pages ==
* [[Folate metabolism]]
* [[Tetrahydrofolate]]
* [[Purine synthesis]]
* [[One-carbon metabolism]]

[[Category:Biochemistry]]
[[Category:Coenzymes]]
[[Category:Folate]]