Editing TAS1R1

'''TAS1R1''' is a protein that in humans is encoded by the TAS1R1 gene. It is one of the three members of the [[Taste receptor]] family of proteins. TAS1R1 combines with another protein, [[TAS1R2]], to form a [[G protein-coupled receptor]] that functions as a sweet taste receptor. This receptor is present in taste buds on the tongue and other regions of the mouth and throat.

== Function ==

The TAS1R1 protein is a part of the class C group of [[G protein-coupled receptor]]s, which are characterized by a large extracellular domain that forms a Venus flytrap module. This module is where the taste molecule binds. The TAS1R1 protein combines with the TAS1R2 protein to form a receptor that responds to the sweet molecules in food. When these molecules bind to the receptor, it activates the G protein, which then triggers a series of reactions that send a signal to the brain that something sweet has been tasted.

== Clinical significance ==

Mutations in the TAS1R1 gene can lead to a reduced ability to taste umami, a savory taste that is often associated with meats and broths. This condition is known as [[ageusia]]. In addition, variations in the TAS1R1 gene have been associated with differences in individual's preference for sweet foods and their consumption of carbohydrates and alcohol.

== See also ==
* [[Taste receptor]]
* [[G protein-coupled receptor]]
* [[TAS1R2]]
* [[Ageusia]]

== References ==
<references />

== External links ==
* [https://www.ncbi.nlm.nih.gov/gene/80835 NCBI Gene]
* [https://www.uniprot.org/uniprot/Q7RTX1 UniProt]

[[Category:G protein-coupled receptors]]
[[Category:Taste]]
[[Category:Human proteins]]
{{G protein-coupled receptors}}
{{Taste}}
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