Editing TAP1

'''TAP1''' (Transporter 1, ATP-binding cassette sub-family B) is a [[protein]] that in humans is encoded by the TAP1 [[gene]]. It is a member of the [[ABC transporter]] family, which are integral membrane proteins that utilize ATP to drive the transport of various molecules across the [[cell membrane]].

== Function ==
TAP1 is involved in the transport of [[antigen]]s from the [[cytoplasm]] to the [[endoplasmic reticulum]] for association with [[MHC class I]] molecules. It also interacts with the [[viral]] [[proteins]] of certain [[viruses]], preventing the transport of the antigenic peptides into the endoplasmic reticulum.

== Clinical significance ==
Mutations in the TAP1 gene can lead to [[bare lymphocyte syndrome]], a type of [[MHC class I deficiency]]. This can result in a variety of [[immune disorders]], including increased susceptibility to viral infections.

== Structure ==
The TAP1 protein is composed of two subunits, each of which has six [[transmembrane domain]]s. The protein also contains an ATP-binding domain, which is responsible for the energy-dependent transport of antigens.

== Interactions ==
TAP1 has been shown to [[protein-protein interaction|interact]] with:
* [[TAP2]]
* [[Tapasin]]
* [[Calreticulin]]
* [[ERp57]]

== See also ==
* [[ATP-binding cassette transporter]]
* [[MHC class I]]

== References ==
<references />

== External links ==
* [https://www.ncbi.nlm.nih.gov/gene/6890 TAP1] at the US National Library of Medicine [[Medical Subject Headings]] (MeSH)

[[Category:ABC transporters]]
[[Category:Proteins]]
[[Category:Genes]]
[[Category:Immunology]]
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