Editing S1PR3

{{Infobox protein
| name = Sphingosine-1-phosphate receptor 3
| image = 
| caption = 
| width = 
| HGNCid = 10631
| symbol = S1PR3
| alt_symbols = EDG-3
| EntrezGene = 1903
| OMIM = 601974
| RefSeq = NM_005226
| UniProt = Q99500
| PDB = 
| ECnumber = 
| chromosomal_location = 9q22.1
}}

'''Sphingosine-1-phosphate receptor 3''' ('''S1PR3''') is a [[G protein-coupled receptor]] that binds the [[bioactive lipid]] [[sphingosine-1-phosphate]] (S1P). It is part of the [[sphingosine-1-phosphate receptor]] family, which plays a crucial role in various physiological processes.

==Structure==
S1PR3 is a member of the [[G protein-coupled receptor]] (GPCR) superfamily, characterized by seven transmembrane domains. The receptor is encoded by the '''S1PR3''' gene located on chromosome 9q22.1. The protein structure allows it to interact with [[sphingosine-1-phosphate]], a signaling molecule involved in numerous cellular functions.

==Function==
S1PR3 is involved in the regulation of several physiological processes, including:

* [[Vascular development]] and [[angiogenesis]]
* [[Immune cell trafficking]]
* [[Cardiovascular function]]
* [[Inflammatory response]]

The receptor mediates its effects through coupling with different [[G proteins]], leading to the activation of various downstream signaling pathways.

==Expression==
S1PR3 is expressed in a variety of tissues, including the [[endothelial cells]] of blood vessels, [[smooth muscle cells]], and [[immune cells]]. Its expression pattern suggests a role in both vascular and immune system functions.

==Clinical Significance==
Alterations in S1PR3 signaling have been implicated in several pathological conditions, such as:

* [[Atherosclerosis]]
* [[Hypertension]]
* [[Autoimmune diseases]]
* [[Cancer]]

Research is ongoing to develop therapeutic agents targeting S1PR3 for the treatment of these conditions.

==See Also==
* [[Sphingosine-1-phosphate receptor]]
* [[G protein-coupled receptor]]
* [[Bioactive lipid]]

==External Links==
* [https://www.wikimd.com/wiki/S1PR3 S1PR3 on WikiMD]
* [https://www.ncbi.nlm.nih.gov/gene/1903 S1PR3 Gene - NCBI]

{{G protein-coupled receptors}}
{{Sphingolipids}}

[[Category:Receptors]]
[[Category:G protein-coupled receptors]]
[[Category:Human proteins]]
[[Category:Chromosome 9 genes]]