Editing RAG2


{{Infobox gene
| name = RAG2
| image = <!-- Image removed -->
| caption = <!-- Caption removed -->
| HGNCid = 9830
| symbol = RAG2
| altSymbols = 
| EntrezGene = 5897
| OMIM = 179620
| RefSeq = NM_000536
| UniProt = P55895
| chromosome = 11
| arm = p
| band = 13
}}

'''RAG2''' (Recombination Activating Gene 2) is a [[gene]] that plays a crucial role in the [[immune system]] by enabling the [[recombination]] of [[immunoglobulin]] and [[T cell receptor]] genes. This process is essential for the development of [[B cells]] and [[T cells]], which are critical components of the [[adaptive immune system]].

== Function ==
The RAG2 gene, along with [[RAG1]], is responsible for the initiation of [[V(D)J recombination]], a mechanism that generates diverse [[antigen receptors]] necessary for the immune system to recognize a wide array of pathogens. The RAG2 protein forms a complex with the RAG1 protein, and together they introduce double-strand breaks at specific sites in the [[DNA]] of developing lymphocytes.

== Clinical Significance ==
Mutations in the RAG2 gene can lead to severe immunodeficiency disorders, such as [[Severe Combined Immunodeficiency]] (SCID) and [[Omenn syndrome]]. These conditions are characterized by a lack of functional B and T cells, leading to increased susceptibility to infections.

== Research ==
Studies on RAG2 have provided insights into the mechanisms of [[genomic instability]] and the development of [[lymphoid malignancies]]. Understanding the function and regulation of RAG2 is crucial for developing therapies for immunodeficiency disorders and certain types of [[cancer]].

== See Also ==
* [[RAG1]]
* [[V(D)J recombination]]
* [[Adaptive immune system]]
* [[Severe Combined Immunodeficiency]]

== References ==
<references />

== External Links ==
* [RAG2 Gene - Genetics Home Reference](https://ghr.nlm.nih.gov/gene/RAG2)
* [RAG2 - GeneCards](https://www.genecards.org/cgi-bin/carddisp.pl?gene=RAG2)

[[Category:Genes on human chromosome 11]]
[[Category:Immune system]]
[[Category:Immunology]]
[[Category:Genetics]]