Editing IRF9

'''IRF9''' (Interferon Regulatory Factor 9) is a [[protein]] that in humans is encoded by the ''IRF9'' [[gene]]. It is a member of the [[interferon regulatory factors]] (IRFs) family, which are transcription factors that play a crucial role in the [[immune system]].

== Function ==

IRF9 is a key component of the [[interferon]]-stimulated gene factor 3 (ISGF3) complex, which is responsible for the transcriptional regulation of genes induced by type I interferon. The ISGF3 complex is composed of IRF9 and the [[STAT1]]-[[STAT2]] heterodimer. Upon stimulation by type I interferons, this complex translocates to the [[nucleus]] and binds to interferon-stimulated response elements (ISRE) in the promoters of interferon-stimulated genes (ISGs), leading to their transcription.

== Clinical significance ==

Mutations in the ''IRF9'' gene have been associated with severe viral diseases due to impaired type I interferon responses. Moreover, IRF9 has been implicated in the pathogenesis of [[autoimmune diseases]] such as [[systemic lupus erythematosus]] and [[rheumatoid arthritis]].

== See also ==

* [[Interferon regulatory factors]]
* [[Interferon]]
* [[STAT1]]
* [[STAT2]]

== References ==

<references />

== External links ==

* [https://www.ncbi.nlm.nih.gov/gene/10379 IRF9] at the National Center for Biotechnology Information

[[Category:Transcription factors]]
[[Category:Interferon]]
[[Category:Immune system]]
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