Editing IL17B

{{Infobox protein
| name = IGSF2
| image = 
| caption = 
| symbol = IGSF2
| alt_symbols = CD101
| EntrezGene = 9398
| HGNCid = 6080
| OMIM = 606662
| RefSeq = NM_005534
| UniProt = Q93033
}}

'''IGSF2''' (Immunoglobulin Superfamily Member 2), also known as '''CD101''', is a protein encoded by the '''IGSF2''' gene in humans. This protein is a member of the immunoglobulin superfamily, which is characterized by the presence of immunoglobulin-like domains.

==Structure==
IGSF2 is a type I transmembrane protein that contains multiple immunoglobulin-like domains. These domains are involved in protein-protein interactions and are crucial for the protein's role in the immune system. The extracellular region of IGSF2 is composed of several Ig-like domains, which are typical of proteins involved in cell adhesion and immune response.

==Function==
IGSF2 plays a significant role in the immune system. It is expressed on the surface of various immune cells, including T cells, B cells, and dendritic cells. The protein is involved in the regulation of immune responses, particularly in the modulation of T cell activation and proliferation. IGSF2 has been implicated in the suppression of T cell responses, which suggests a role in maintaining immune homeostasis and preventing autoimmunity.

==Clinical Significance==
Alterations in the expression or function of IGSF2 have been associated with various immune-related disorders. For instance, changes in IGSF2 expression have been observed in autoimmune diseases, where the regulation of T cell activity is disrupted. Additionally, IGSF2 may play a role in the immune evasion mechanisms of certain cancers, where its expression can influence the tumor microenvironment and immune surveillance.

==Research Directions==
Current research on IGSF2 is focused on understanding its precise role in immune regulation and its potential as a therapeutic target. Studies are exploring how modulation of IGSF2 activity could be used to enhance immune responses against tumors or to suppress unwanted immune activity in autoimmune diseases.

==Also see==
* [[Immunoglobulin superfamily]]
* [[T cell activation]]
* [[Autoimmune disease]]
* [[Immune system]]

{{Immunology}}
{{Protein}}

[[Category:Immunology]]
[[Category:Proteins]]
[[Category:Human proteins]]