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IGFBP1
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'''IGFBP1''' (Insulin-like Growth Factor Binding Protein 1) is a protein that in humans is encoded by the IGFBP1 gene. It is one of six binding proteins (IGFBP1-6) that have high affinity for [[Insulin-like Growth Factors]] (IGFs). == Function == IGFBP1 is a secreted protein that binds to both [[Insulin-like Growth Factor 1|IGF-I]] and [[Insulin-like Growth Factor 2|IGF-II]] with high affinity. The binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. IGFBP1 is expressed in many tissues, including liver, brain, heart, and kidneys. It plays a crucial role in regulating IGF bioavailability, and thus, cell growth and survival. == Clinical Significance == Alterations in the serum concentration of IGFBP1 have been associated with a variety of diseases. High levels of IGFBP1 have been observed in conditions such as [[Type 1 Diabetes]], [[Fasting]], and [[Physical Exercise]]. Conversely, low levels of IGFBP1 are associated with [[Type 2 Diabetes]], [[Insulin Resistance]], and [[Obesity]]. In addition, IGFBP1 has been implicated in the development and progression of several types of cancer, including [[Breast Cancer]], [[Prostate Cancer]], and [[Colorectal Cancer]]. It is thought that IGFBP1 may influence cancer cell growth and survival by modulating the bioavailability of IGFs. == Research == Research into IGFBP1 has focused on understanding its role in health and disease, and its potential as a therapeutic target. Studies have investigated the regulation of IGFBP1 expression, its interaction with IGFs and IGF receptors, and its effects on cell growth and survival. == See Also == * [[Insulin-like Growth Factor]] * [[Insulin-like Growth Factor 1]] * [[Insulin-like Growth Factor 2]] * [[Insulin Resistance]] * [[Type 1 Diabetes]] * [[Type 2 Diabetes]] * [[Breast Cancer]] * [[Prostate Cancer]] * [[Colorectal Cancer]] [[Category:Proteins]] [[Category:Human Proteins]] [[Category:Growth Factors]] [[Category:Diabetes]] [[Category:Cancer]] {{Protein-stub}} {{Medicine-stub}} {{No image}} __NOINDEX__
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