Editing HPG80

'''hPG80''' is a [[protein]] that is encoded by the [[gene]] C80 in humans. It is a member of the [[gastrin]]/[[cholecystokinin]] family of proteins, which are known to play a crucial role in various [[physiological]] processes, including [[cell growth]], [[cell differentiation]], and [[apoptosis]].

== Structure ==
The hPG80 protein is composed of 80 [[amino acids]] and has a molecular weight of approximately 10 kDa. It is characterized by a highly conserved sequence of seven amino acids, known as the gastrin/cholecystokinin motif, which is essential for its biological activity.

== Function ==
hPG80 is primarily involved in the regulation of [[gastric acid]] secretion and [[gastric motility]]. It stimulates the release of gastric acid by binding to the [[CCK2 receptor]] on the surface of [[parietal cells]] in the stomach. In addition, it promotes gastric motility by acting on the [[smooth muscle]] cells of the stomach.

hPG80 also plays a role in cell growth and differentiation. It has been shown to stimulate the proliferation of various types of cells, including [[gastric mucosal cells]] and [[pancreatic cancer cells]]. Moreover, it promotes the differentiation of [[enteroendocrine cells]], which are responsible for the production of various hormones in the gut.

== Clinical significance ==
Abnormal expression of hPG80 has been associated with several types of cancer, including [[gastric cancer]], [[pancreatic cancer]], and [[colorectal cancer]]. It has been suggested that hPG80 may serve as a potential [[biomarker]] for these cancers.

== See also ==
* [[Gastrin]]
* [[Cholecystokinin]]
* [[CCK2 receptor]]
* [[Parietal cell]]
* [[Gastric acid]]
* [[Gastric motility]]

== References ==
<references />

[[Category:Proteins]]
[[Category:Genes]]
[[Category:Gastroenterology]]
[[Category:Oncology]]
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== HPG80 ==
<gallery>
File:Capture_d’écran_2020-06-23_à_20.23.55.png|Capture d’écran 2020-06-23 à 20.23.55
File:Variations_des_taux_de_hPG80_et_AFP.png|Variations des taux de hPG80 et AFP
</gallery>