Editing HOXB13

'''HOXB13''' is a protein that in humans is encoded by the '''HOXB13''' gene. This gene is part of the [[homeobox]] gene family, which are critical in the formation and development of the body plan of an organism. The HOXB13 gene is specifically involved in the development of the [[prostate]] and [[hair follicles]].

== Function ==
The HOXB13 gene provides instructions for making a protein that plays a crucial role in the development of tissues and organs during embryonic development. This protein is a [[transcription factor]], which means it attaches (binds) to specific regions of DNA and helps control the activity of particular genes.

== Clinical significance ==
Mutations in the HOXB13 gene have been associated with an increased risk of [[prostate cancer]]. A specific mutation in this gene, known as G84E, has been found to significantly increase the risk of hereditary prostate cancer. This mutation changes a single protein building block (amino acid) in the HOXB13 protein, which likely alters the protein's function.

== See also ==
* [[Homeobox]]
* [[Prostate cancer]]
* [[Transcription factor]]

== References ==
<references />

== External links ==
* [https://www.ncbi.nlm.nih.gov/gene/ HOXB13] at the National Center for Biotechnology Information

[[Category:Genes]]
[[Category:Transcription factors]]
[[Category:Prostate cancer]]
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