Editing HLA-E

'''HLA-E''' is a [[human leukocyte antigen]] that is part of the [[Major Histocompatibility Complex]] (MHC) class I molecules. It is encoded by the ''HLA-E'' gene and is expressed in almost all cells. HLA-E plays a crucial role in the [[immune system]], particularly in the regulation of [[natural killer cells]].

== Function ==
HLA-E binds to a subset of [[peptides]] derived from the leader sequences of other MHC class I molecules and presents these peptides to the [[T cells]] and natural killer cells. This interaction plays a significant role in the immune response, as it helps the immune system distinguish between self and non-self cells.

== Clinical significance ==
Alterations in the ''HLA-E'' gene have been associated with various diseases. For instance, certain ''HLA-E'' alleles have been linked to an increased susceptibility to [[HIV]] infection and progression to [[AIDS]]. Moreover, ''HLA-E'' polymorphisms have been implicated in [[autoimmune diseases]], such as [[rheumatoid arthritis]] and [[type 1 diabetes]].

== See also ==
* [[Human leukocyte antigen]]
* [[Major Histocompatibility Complex]]
* [[Natural killer cell]]
* [[T cell]]

== References ==
<references />

== External links ==
* [https://www.ncbi.nlm.nih.gov/gene/3133 HLA-E] at the US National Library of Medicine [[Medical Subject Headings]] (MeSH)

[[Category:Human proteins]]
[[Category:Immune system]]
[[Category:HLA]]

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