Editing GDF11

'''GDF11''' or '''Growth Differentiation Factor 11''' is a [[protein]] that in humans is encoded by the GDF11 [[gene]]. It belongs to the [[Transforming growth factor beta|TGF-beta]] superfamily of proteins. 

== Function ==
GDF11 is a highly conserved [[regulatory protein]], which means it controls the activity of other genes. It plays a crucial role in [[embryonic development]], including the development of the [[anterior/posterior]] patterning of the [[vertebrate]] [[skeleton]], [[organogenesis]], and [[neurogenesis]]. It is also involved in the regulation of [[aging]] and [[age-related diseases]].

== Structure ==
The GDF11 protein is a [[dimer]], which means it is composed of two identical subunits. Each subunit is made up of a chain of [[amino acids]]. The protein is synthesized as a precursor molecule that is subsequently cleaved to form the mature protein.

== Role in Aging ==
Recent studies have suggested that GDF11 levels decline with age and that restoring GDF11 levels in aged mice can reverse some signs of aging, including [[cardiac hypertrophy]] and [[neurodegeneration]]. However, these findings are controversial and further research is needed to confirm these results and to understand the mechanisms involved.

== Clinical Significance ==
Alterations in the function of GDF11 have been implicated in a variety of diseases, including [[cancer]], [[cardiovascular disease]], and [[neurodegenerative diseases]]. Therefore, GDF11 is a potential target for therapeutic interventions in these diseases.

== See Also ==
* [[Growth differentiation factor]]
* [[TGF beta signaling pathway]]
* [[Aging]]
* [[Regenerative medicine]]

== References ==
<references />

[[Category:Growth factors]]
[[Category:TGF-beta domain]]
[[Category:Human proteins]]
[[Category:Genes on human chromosome 12]]
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