Editing COPII

'''COPII‏‎''' is a type of [[coat protein]] that is involved in the transport of proteins from the [[endoplasmic reticulum]] (ER) to the [[Golgi apparatus]]. This process is known as [[ER to Golgi transport]], which is a crucial step in the [[secretory pathway]] of eukaryotic cells.

== Structure ==
COPII is composed of five different proteins: [[Sec23]], [[Sec24]], [[Sec13]], [[Sec31]], and [[Sar1]]. These proteins assemble into a coat that surrounds transport vesicles as they bud from the ER. The assembly of the COPII coat is regulated by the [[GTPase]] activity of Sar1.

== Function ==
The primary function of COPII is to transport proteins from the ER to the Golgi apparatus. This is achieved by the formation of [[transport vesicles]] that bud from the ER, which are then transported to the Golgi apparatus where they fuse and deliver their cargo. The proteins transported by COPII include both [[soluble proteins]] that reside in the lumen of the ER and [[transmembrane proteins]] that are embedded in the ER membrane.

== Role in Disease ==
Mutations in the genes encoding COPII proteins have been linked to several human diseases, including [[Cranio-lenticulo-sutural dysplasia]] and [[Cole-Carpenter syndrome]]. These diseases are characterized by skeletal abnormalities, and are thought to result from defects in the transport of specific proteins that are important for bone development.

== See Also ==
* [[Coat protein]]
* [[Endoplasmic reticulum]]
* [[Golgi apparatus]]
* [[ER to Golgi transport]]
* [[Secretory pathway]]
* [[Transport vesicle]]
* [[GTPase]]
* [[Soluble protein]]
* [[Transmembrane protein]]
* [[Cranio-lenticulo-sutural dysplasia]]
* [[Cole-Carpenter syndrome]]

[[Category:Protein families]]
[[Category:Cell biology]]
[[Category:Membrane biology]]
{{Cell-bio-stub}}
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File:PDB_2gao_EBI.jpg|COPII
File:CopIIcomplexbet1.png|COPII
File:CopIIcomplexsedt5.png|COPII
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