Editing CMKLR1

'''CMKLR1''' (Chemokine-like receptor 1) is a [[protein]] that in humans is encoded by the ''CMKLR1'' [[gene]]. It is also known as ChemR23, DEZ, or ChemerinR. CMKLR1 is a member of the [[G protein-coupled receptor]] family, and it has been implicated in various biological processes, including [[inflammation]], [[adipogenesis]], and [[cardiovascular disease]].

== Function ==

CMKLR1 is a receptor for the chemoattractant protein [[Chemerin]], and it mediates its effects through [[G protein]]-coupled signaling pathways. The activation of CMKLR1 by Chemerin can lead to intracellular [[calcium]] release and the activation of the [[phosphatidylinositol 3-kinase]] pathway.

In addition to its role in inflammation, CMKLR1 has been shown to play a role in the regulation of adipogenesis. It is expressed in [[adipose tissue]], and its activation can promote the differentiation of [[pre-adipocytes]] into mature adipocytes.

== Clinical significance ==

Alterations in the function or expression of CMKLR1 have been associated with various diseases. For example, increased expression of CMKLR1 has been observed in [[atherosclerotic]] plaques, suggesting a role in the development of [[cardiovascular disease]]. In addition, mutations in the ''CMKLR1'' gene have been linked to [[obesity]] and [[metabolic syndrome]].

== See also ==

* [[G protein-coupled receptor]]
* [[Chemerin]]
* [[Adipogenesis]]
* [[Cardiovascular disease]]

== References ==

<references />

== External links ==

* [https://www.ncbi.nlm.nih.gov/gene/1240 CMKLR1] at the [[National Center for Biotechnology Information]]

[[Category:G protein-coupled receptors]]
[[Category:Human proteins]]
[[Category:Genes]]

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