Editing CDH15

'''CDH15''' is a gene that in humans encodes the cadherin 15 protein, also known as M-cadherin. This protein is a type of [[cadherin]], which are calcium-dependent cell adhesion proteins. They play important roles in cell-cell adhesion, ensuring that cells within tissues are bound together. 

== Function ==
The CDH15 gene is a member of the [[cadherin]] superfamily. The encoded protein, M-cadherin, is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. 

== Clinical significance ==
Mutations in the CDH15 gene have been associated with [[congenital heart disease]] and [[autism spectrum disorder]]. In addition, the gene has been implicated in certain types of cancer, including [[breast cancer]] and [[prostate cancer]].

== See also ==
* [[Cadherin]]
* [[Congenital heart disease]]
* [[Autism spectrum disorder]]
* [[Breast cancer]]
* [[Prostate cancer]]

== References ==
<references />

== External links ==
* [https://www.ncbi.nlm.nih.gov/gene/1013 CDH15] at the National Center for Biotechnology Information

[[Category:Genes]]
[[Category:Human proteins]]
[[Category:Cell adhesion proteins]]
[[Category:Cadherins]]

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