Editing CDH12

'''CDH12''' is a gene that in humans encodes the protein Cadherin 12, which is a type of [[cadherin]]. Cadherins are a class of type-1 transmembrane proteins that play important roles in cell adhesion, ensuring that cells within tissues are bound together. They are dependent on calcium (Ca2+) ions to function, hence their name.

== Function ==
The CDH12 gene is part of the cadherin superfamily, which includes [[calcium-dependent adhesion proteins]]. Cadherins are integral membrane proteins that mediate calcium-dependent cell-cell adhesion. The encoded protein is a type 2 (atypical) cadherin, which is characterized by an extracellular domain consisting of 7 cadherin repeats. The protein also has a unique cytoplasmic domain and is involved in the regulation of the [[neural crest]] migration and [[neuronal differentiation]].

== Clinical significance ==
Alterations in the CDH12 gene have been associated with various diseases. For example, mutations in this gene have been linked to [[congenital heart disease]] and [[neurodevelopmental disorders]]. Further research is needed to fully understand the role of CDH12 in human health and disease.

== See also ==
* [[Cadherin]]
* [[Calcium-dependent adhesion proteins]]
* [[Neural crest]]
* [[Neuronal differentiation]]
* [[Congenital heart disease]]
* [[Neurodevelopmental disorders]]

== References ==
<references />

[[Category:Genes]]
[[Category:Proteins]]
[[Category:Cell adhesion]]
[[Category:Neuroscience]]
[[Category:Cardiology]]
[[Category:Developmental biology]]

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