Editing CD30

'''CD30''' is a [[cell membrane]] protein of the [[tumor necrosis factor receptor]] family and [[tumor marker]]. CD30 is also known as '''TNFRSF8''' and is a cell membrane protein of the tumor necrosis factor receptor superfamily. The encoded protein is a receptor for the [[lymphocyte]]-expressed ligand CD30L. CD30 is expressed on activated, but not on resting, [[T cells]] and [[B cells]].

== Function ==

CD30 has a role in [[cell proliferation]] and [[differentiation]]. It is thought to have a role in [[lymphoma]] pathogenesis and may have a role in the prognosis of some types of lymphoma. CD30 is also associated with [[anaplastic large cell lymphoma]] and is a defining feature of this type of non-Hodgkin lymphoma.

== Clinical significance ==

CD30 is used in the diagnosis of lymphomas. It is expressed in [[Hodgkin's lymphoma]], [[anaplastic large cell lymphoma]], and embryonal [[carcinoma]]. CD30 expression is often associated with a poorer prognosis in non-Hodgkin lymphoma. 

== Therapeutic use ==

CD30 is the target of the FDA-approved [[antibody-drug conjugate]] brentuximab vedotin (Adcetris), used in the treatment of Hodgkin lymphoma and anaplastic large cell lymphoma.

== See also ==
* [[CD30 ligand]]
* [[Tumor necrosis factor receptor]]
* [[Anaplastic large cell lymphoma]]
* [[Hodgkin's lymphoma]]

== References ==
<references />

== External links ==
* [https://www.wikimd.com/wiki/CD30 WikiMD]

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[[Category:Proteins]]
[[Category:Tumor markers]]
[[Category:Lymphoma]]
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