Editing CD155

'''CD155''', also known as the '''poliovirus receptor''' or '''PVR''', is a protein that in humans is encoded by the CD155 gene. It is a member of the [[immunoglobulin superfamily]] and mediates cell adhesion with other cells. CD155 is also a receptor for poliovirus in humans, hence its name.

== Function ==
CD155 is a transmembrane protein that is part of the [[immunoglobulin superfamily]]. It is involved in cell adhesion and in the immune response. CD155 is also a receptor for poliovirus, the virus that causes [[polio]]. It is expressed in many tissues including the [[central nervous system]], where poliovirus replication occurs.

== Clinical significance ==
CD155 has been found to be overexpressed in several types of cancer, including [[lung cancer]], [[breast cancer]], and [[colorectal cancer]]. This overexpression has been associated with increased tumor growth and metastasis. CD155 is also a target for several immunotherapies that aim to boost the immune system's ability to fight cancer.

== See also ==
* [[Cluster of differentiation]]
* [[Immunoglobulin superfamily]]
* [[Polio]]

== References ==
<references />

== External links ==
* [https://www.ncbi.nlm.nih.gov/gene/58133 CD155] at the US National Library of Medicine Medical Subject Headings (MeSH)

[[Category:Clusters of differentiation]]
[[Category:Immunoglobulin superfamily]]
[[Category:Cell adhesion proteins]]
[[Category:Transmembrane proteins]]

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